Product details
Background:
ASZ1 rabbit pAb
Ucallm_WP7049-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | ASZ1 |
| Reactivity | Human, Mouse |
| Applications | WB |
| MW(Calculated) | 52kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human ASZ1 |
| Specificity | This antibody detects endogenous levels of ASZ1 at Human, Mouse |
| Gene Name | ASZ1 ALP1 ANKL1 C7orf7 GASZ |
| Protein Name | Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1 (Ankyrin-like protein 1) (Germ cell-specific ankyrin, SAM and basic leucine zipper domain-containing protein) |
| Other Name | |
| Species | Human |
| Gene ID | 136991 |
| Uniprot | Q8WWH4, |
| Species.1 | Mouse |
| Gene ID.1 | 74068 |
| Uniprot.1 | Q8VD46 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasm . Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. Specifically localizes to pi-bodies, a subset of the nuage which contains primary piRNAs (By similarity). . |
| Tissue Expression | Expressed exclusively in the testis and ovary and at higher levels in the adult testis compared with the adult ovary. |
| Signaling_pathway | |
| Research Areas | |
| Function | Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in the regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation (By similarity). |
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