Product details
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TMEM106A rabbit pAb
Ucallm_WP7756-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | TMEM106A |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 29kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human TMEM106A |
| Specificity | This antibody detects endogenous levels of TMEM106A at Human, Mouse,Rat |
| Gene Name | TMEM106A |
| Protein Name | Transmembrane protein 106A |
| Other Name | |
| Species | Human |
| Gene ID | 113277 |
| Uniprot | Q96A25, |
| Species.1 | Mouse |
| Gene ID.1 | 217203 |
| Uniprot.1 | Q8VC04, |
| Species.2 | Rat |
| Gene ID.2 | 287722 |
| Uniprot.2 | Q5BK83 |
| Cellular Localization | Cell membrane; Single-pass membrane protein . |
| Tissue Expression | Expressed in renal cells (at protein level) (PubMed:29131025). Expressed in epithelial cells (PubMed:30456879). |
| Signaling_pathway | |
| Research Areas | |
| Function | Activates macrophages and polarizes them into M1-like macrophages through the activation of the MAPK and NF-kappaB signaling pathway. Upon activation, up-regulates the expression of CD80, CD86, CD69 and MHC II on macrophages, and induces the release of pro-inflammatory cytokines such as TNF, IL1B, IL6, CCL2 and nitric oxide (By similarity). May play a role in inhibition of proliferation and migration . |
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