Product details
Background:
MPEG1 rabbit pAb
Ucallm_WP8222-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | MPEG1 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 79kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human MPEG1 |
| Specificity | This antibody detects endogenous levels of MPEG1 at Human, Mouse,Rat |
| Gene Name | MPEG1 |
| Protein Name | Macrophage-expressed gene 1 protein (Macrophage gene 1 protein) (Mpg-1) |
| Other Name | |
| Species | Human |
| Gene ID | 219972 |
| Uniprot | Q2M385, |
| Species.1 | Mouse |
| Gene ID.1 | 17476 |
| Uniprot.1 | A1L314, |
| Species.2 | Rat |
| Gene ID.2 | 64552 |
| Uniprot.2 | Q9WV57 |
| Cellular Localization | [Isoform 1]: Cytoplasmic vesicle membrane; Single-pass type I membrane protein . Bacterial infection induces translocation of the cytoplasmic vesicles to bacterium-containing phagocytic vesicles and fusing of the vesicles. .; [Isoform 2]: Secreted . |
| Tissue Expression | Expressed constitutively in a variety of cell types including macrophages, natural killer cells, neutrophils, keratinocytes and monocytes (PubMed:26402460, PubMed:28705375, PubMed:7888681). In skin, expressed in both hematopoietic and non-hematopoietic cells with expression detected in a variety of cell types including keratinocytes, fibroblasts and endothelial cells (PubMed:30609079). |
| Signaling_pathway | |
| Research Areas | |
| Function | Plays a key role in the innate immune response following bacterial infection by inserting into the bacterial surface to form pores (By similarity). By breaching the surface of phagocytosed bacteria, allows antimicrobial effectors to enter the bacterial periplasmic space and degrade bacterial proteins such as superoxide dismutase sodC which contributes to bacterial virulence (By similarity). Shows antibacterial activity against a wide spectrum of Gram-positive, Gram-negative and acid-fast bacteria . Reduces the viability of the intracytosolic pathogen L.monocytogenes by inhibiting acidification of the phagocytic vacuole of host cells which restricts bacterial translocation from the vacuole to the cytosol (By similarity). Required for the antibacterial activity of reactive oxygen species and nitric oxide (By similarity). |
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