Product details
Background:
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Reticulocalbin 3 rabbit pAb
Ucallm_WP8589-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | RCN3 |
| Reactivity | Human, Mouse |
| Applications | WB |
| MW(Calculated) | 36kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human Reticulocalbin 3 |
| Specificity | This antibody detects endogenous levels of Reticulocalbin 3 at Human, Mouse |
| Gene Name | RCN3 UNQ239/PRO272 |
| Protein Name | Reticulocalbin-3 (EF-hand calcium-binding protein RLP49) |
| Other Name | |
| Species | Human |
| Gene ID | 57333 |
| Uniprot | Q96D15, |
| Species.1 | Mouse |
| Gene ID.1 | 52377 |
| Uniprot.1 | Q8BH97 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Endoplasmic reticulum lumen . |
| Tissue Expression | Widely expressed. |
| Signaling_pathway | |
| Research Areas | |
| Function | Probable molecular chaperone assisting protein biosynthesis and transport in the endoplasmic reticulum . Required for the proper biosynthesis and transport of pulmonary surfactant-associated protein A/SP-A, pulmonary surfactant-associated protein D/SP-D and the lipid transporter ABCA3 (By similarity). By regulating both the proper expression and the degradation through the endoplasmic reticulum-associated protein degradation pathway of these proteins plays a crucial role in pulmonary surfactant homeostasis (By similarity). Has an anti-fibrotic activity by negatively regulating the secretion of type I and type III collagens . This calcium-binding protein also transiently associates with immature PCSK6 and regulates its secretion . |
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