Product details
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TTLL12 rabbit pAb
Ucallm_WP8996-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | TTLL12 |
| Reactivity | Human, Mouse |
| Applications | WB |
| MW(Calculated) | 71kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human TTLL12 |
| Specificity | This antibody detects endogenous levels of TTLL12 at Human, Mouse |
| Gene Name | TTLL12 KIAA0153 |
| Protein Name | Tubulin--tyrosine ligase-like protein 12 |
| Other Name | |
| Species | Human |
| Gene ID | 23170 |
| Uniprot | Q14166, |
| Species.1 | Mouse |
| Gene ID.1 | 223723 |
| Uniprot.1 | Q3UDE2 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasm . Midbody . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, spindle . Nucleus . Predominantly localizes in the cytoplasm (PubMed:28011935). Partially colocalizes with vimentin in prostate cancer cells (PubMed:20162578). . |
| Tissue Expression | Expressed in the basal layer of prostate and endothelial cells. Increased expression in prostatic intraepithelial neoplasia and metastatic lesions. |
| Signaling_pathway | |
| Research Areas | |
| Function | Negatively regulates post-translational modifications of tubulin, including detyrosination of the C-terminus and polyglutamylation of glutamate residues . Also, indirectly promotes histone H4 trimethylation at 'Lys-20' (H4K20me3) . Probably by controlling tubulin and/or histone H4 post-translational modifications, plays a role in mitosis and in maintaining chromosome number stability . During RNA virus-mediated infection, acts as a negative regulator of the DDX58/RIG-I pathway by preventing MAVS binding to TBK1 and IKBKE . |
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