Price range: $268.00 through $328.00
Background:
This gene encodes a calcium-binding mitochondrial carrier protein. The encoded protein localizes to the mitochondria and is involved in the exchange of aspartate for glutamate across the inner mitochondrial membrane. Polymorphisms in this gene may be associated with autism, and mutations in this gene may also be a cause of global cerebral hypomyelination. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Apr 2012],
| Target | ARALAR |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 75kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Modification | |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:20000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#YS0004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Source | |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Purity | |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human CMC1. AA range:391-440 |
| Sequence | |
| Specificity | ARALAR Polyclonal Antibody detects endogenous levels of ARALAR protein. |
| Gene Name | SLC25A12 |
| Protein Name | Calcium-binding mitochondrial carrier protein Aralar1 |
| Other Name | SLC25A12; / ARALAR1; / Calcium-binding mitochondrial carrier protein Aralar1; / Mitochondrial aspartate glutamate carrier 1; / Solute carrier family 25 member 12 |
| Species | Human |
| Gene ID-1 | 8604 |
| Uniprot | O75746, |
| Species.1 | Mouse |
| Gene ID-2 | |
| Uniprot.1 | Q8BH59 |
| Species.2 | |
| Gene ID-3 | |
| Uniprot.2 | |
| Organism-4 | |
| Gene ID-4 | |
| SwissProt-4 | |
| Background | This gene encodes a calcium-binding mitochondrial carrier protein. The encoded protein localizes to the mitochondria and is involved in the exchange of aspartate for glutamate across the inner mitochondrial membrane. Polymorphisms in this gene may be associated with autism, and mutations in this gene may also be a cause of global cerebral hypomyelination. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Apr 2012], |
| Cellular Localization | Mitochondrion inner membrane; Multi-pass membrane protein . |
| Tissue Expression | Expressed predominantly in the heart and skeletal muscle, weakly in brain and kidney. |
| Signaling_pathway | |
| Research Areas | |
| Function | Function:Calcium-dependent mitochondrial aspartate and glutamate carrier. May have a function in the urea cycle.,miscellaneous:Binds calcium.,similarity:Belongs to the mitochondrial carrier family.,similarity:Contains 3 Solcar repeats.,similarity:Contains 4 EF-hand domains.,tissue specificity:High levels in heart and skeletal muscle, low in brain and very low in kidney., |
| RRID |
