Name: BMP-8 Polyclonal Antibody
SKU: WP11289
Price: 268 USD
Availability: InStock

BMP-8 Polyclonal Antibody

Ucallm_WP11289-50

Price range: $268.00 through $328.00

Size

100μl

50μl

Clear

SKU: WP11289-100

Enter the quantity you would like, or drag the panel to find the quantity and price that best for you

Bulk Quote Authorize OEM & ODM

Product details

Background:

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The encoded protein stimulates thermogenesis in brown adipose tissue. Expression of this gene may be downregulated in pancreatic cancer. This gene may have arose from a gene duplication event and its gene duplicate is also present on chromosome 1. [provided by RefSeq, Jul 2016],

Specifications

Size	50μL/100μL
Target	BMP-8
Reactivity	Human, Mouse
Applications	IHC, IF, ELISA
MW(Calculated)	45kD
MW(Observed)
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	IHC 1:100-1:300; ELISA 1:40000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	The antiserum was produced against synthesized peptide derived from human BMP-8. AA range:41-90
Specificity	BMP-8 Polyclonal Antibody detects endogenous levels of BMP-8 protein.
Gene Name	BMP8A/BMP8B
Protein Name	Bone morphogenetic protein 8A/B
Other Name	BMP8B; / BMP8; / Bone morphogenetic protein 8B; / BMP-8; / BMP-8B; / Osteogenic protein 2; / OP-2; / BMP8A; / Bone morphogenetic protein 8A; / BMP-8A
Species	Human
Gene ID	656
Uniprot	P34820;Q7Z5Y6
Species.1
Gene ID.1
Uniprot.1
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Secreted .
Tissue Expression	Hippocampus,Testis,
Signaling_pathway	Environmental Information Processing >> Signal transduction >> TGF-beta signaling pathway;Environmental Information Processing >> Signal transduction >> Hippo signaling pathway;Environmental Information Processing >> Signaling molecules and interaction >> Cytokine-cytokine receptor interaction
Research Areas	>>Cytokine-cytokine receptor interaction; / >>TGF-beta signaling pathway; / >>Hippo signaling pathway; / >>Thermogenesis
Function	Function:Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis.,online information:Bone morphogenetic protein 8b entry,similarity:Belongs to the TGF-beta family.,subunit:Homodimer; disulfide-linked.,