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Home/Reagents/Antibody/Primary antibody/Polyclonal Antibody/Rabbit pAb/BTR1 Polyclonal Antibody
SKU: WP11324 Categories: ,

BTR1 Polyclonal Antibody

Ucallm_WP11324-50

Price range: $268.00 through $328.00

SKU: WP11324-100
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Product details

Background:

This gene encodes a voltage-regulated, electrogenic sodium-coupled borate cotransporter that is essential for borate homeostasis, cell growth and cell proliferation. Mutations in this gene have been associated with a number of endothelial corneal dystrophies including recessive corneal endothelial dystrophy 2, corneal dystrophy and perceptive deafness, and Fuchs endothelial corneal dystrophy. Multiple transcript variants encoding different isoforms have been described. [provided by RefSeq, Mar 2010],

Specifications

Size50μL/100μL
TargetBTR1
ReactivityHuman, Mouse
ApplicationsWB, ELISA
MW(Calculated)
MW(Observed)100kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-1:2000; ELISA 1:20000; Not yet tested in other applications.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenThe antiserum was produced against synthesized peptide derived from human SLC4A11. AA range:291-340
SpecificityBTR1 Polyclonal Antibody detects endogenous levels of BTR1 protein.
Gene NameSLC4A11
Protein NameSodium bicarbonate transporter-like protein 11
Other NameSLC4A11; / BTR1; / Sodium bicarbonate transporter-like protein 11; / Bicarbonate transporter-related protein 1; / Sodium borate cotransporter 1; / NaBC1; / Solute carrier family 4 member 11
SpeciesHuman
Gene ID83959
UniprotQ8NBS3,
Species.1Mouse
Gene ID.1
Uniprot.1A2AJN7
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationCell membrane; Multi-pass membrane protein . Basolateral cell membrane; Multi-pass membrane protein .
Tissue ExpressionWidely expressed. Highly expressed in kidney, testis, salivary gland, thyroid, trachea and corneal endothelium. Not detected in retina and lymphocytes.; [Isoform 3]: Expressed in corneal endothelium (at protein level).; [Isoform 5]: The predominant isoform in corneal endothelium (at protein level).
Signaling_pathway
Research Areas
FunctionDisease:Defects in SLC4A11 are the cause of corneal dystrophy and perceptive deafness (CDPD) [MIM:217400]; also known as corneal dystrophy and sensorineural deafness or Harboyan syndrome. CDPD consists of congenital corneal endothelial dystrophy and progressive perceptive deafness. Inheritance is autosomal recessive.,Disease:Defects in SLC4A11 are the cause of corneal endothelial dystrophy type 2 (CHED2) [MIM:217700]; also known as congenital hereditary endothelial dystrophy of cornea. This bilateral corneal dystrophy is characterized by corneal opacification and nystagmus. Inheritance is autosomal recessive.,Function:Transporter involved in borate homeostasis. In the absence of borate, it functions as a Na(+) and OH(-)(H(+)) channel. In the presence of borate functions as an electrogenic Na(+) coupled borate cotransporter.,PTM:Glycosylated.,similarity:Belongs to the anion exchanger (TC 2.A.31) family.,tissue specificity:Widely expressed. Highly expressed in kidney, testis, salivary gland, thyroid, trachea and corneal endothelium. Not detected in retina and lymphocytes.,
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