Name: CYP2J2 Polyclonal Antibody
SKU: WP11891
Price: 268 USD
Availability: InStock

CYP2J2 Polyclonal Antibody

Ucallm_WP11891-50

Price range: $268.00 through $328.00

Size

100μl

50μl

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SKU: WP11891-100

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Product details

Background:

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is thought to be the predominant enzyme responsible for epoxidation of endogenous arachidonic acid in cardiac tissue. Multiple transcript variants have been found for this gene. [provided by RefSeq, Jan 2016],

Specifications

Size	50μL/100μL
Target	CYP2J2
Reactivity	Human, Monkey
Applications	WB, IHC, IF, ELISA
MW(Calculated)
MW(Observed)	58kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:10000; Not yet tested in other applications. / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	The antiserum was produced against synthesized peptide derived from human Cytochrome P450 2J2. AA range:231-280
Specificity	CYP2J2 Polyclonal Antibody detects endogenous levels of CYP2J2 protein.
Gene Name	CYP2J2
Protein Name	Cytochrome P450 2J2
Other Name	CYP2J2; / Cytochrome P450 2J2; / Arachidonic acid epoxygenase; / CYPIIJ2
Species	Human
Gene ID	1573
Uniprot	P51589
Species.1
Gene ID.1
Uniprot.1
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Tissue Expression	Highly expressed in heart, present at lower levels in liver, kidney and skeletal muscle (at protein level).
Signaling_pathway	Organismal Systems >> Sensory system >> Inflammatory mediator regulation of TRP channels
Research Areas	>>Arachidonic acid metabolism; / >>Linoleic acid metabolism; / >>Metabolic pathways; / >>Serotonergic synapse; / >>Inflammatory mediator regulation of TRP channels; / >>Ovarian steroidogenesis; / >>Lipid and atherosclerosis
Function	Catalytic activity:RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O.,cofactor:Heme group.,Function:This enzyme metabolizes arachidonic acid predominantly via a NADPH-dependent olefin epoxidation to all four regioisomeric cis-epoxyeicosatrienoic acids. One of the predominant enzymes responsible for the epoxidation of endogenous cardiac arachidonic acid pools.,online information:CYP2J2 alleles,similarity:Belongs to the cytochrome P450 family.,tissue specificity:Highly expressed in heart, present at lower levels in liver, ileum, jejunum, colon, and kidney.,