Price range: $268.00 through $328.00
Background:
The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein has been shown to possess PPIase activity and, similar to other family members, can bind to the immunosuppressant cyclosporin A. [provided by RefSeq, Jul 2008],
| Size | 50μL/100μL |
| Target | Cyclophilin D |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 40kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC: 1:100-300; ELISA 1:20000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from the C-terminal region of human PPID. AA range:321-370 |
| Specificity | Cyclophilin D Polyclonal Antibody detects endogenous levels of Cyclophilin D protein. |
| Gene Name | PPID |
| Protein Name | Peptidyl-prolyl cis-trans isomerase D |
| Other Name | PPID; / CYP40; / CYPD; / Peptidyl-prolyl cis-trans isomerase D; / PPIase D; / 40 kDa peptidyl-prolyl cis-trans isomerase; / Cyclophilin-40; / CYP-40; / Cyclophilin-related protein; / Rotamase D |
| Species | Human |
| Gene ID | 5481 |
| Uniprot | Q08752, |
| Species.1 | Mouse |
| Gene ID.1 | 67738 |
| Uniprot.1 | Q9CR16, |
| Species.2 | Rat |
| Gene ID.2 | 361967 |
| Uniprot.2 | Q6DGG0 |
| Cellular Localization | Cytoplasm . Nucleus, nucleolus . Nucleus, nucleoplasm . |
| Tissue Expression | Widely expressed. |
| Signaling_pathway | Cellular Processes >> Cell growth and death >> Necroptosis;Cellular Processes >> Cell growth and death >> Cellular senescence;Human Diseases >> Neurodegenerative disease >> Alzheimer disease;Human Diseases >> Neurodegenerative disease >> Pathways of neurodegeneration - multiple diseases |
| Research Areas | >>Necroptosis; / >>Cellular senescence; / >>Alzheimer disease; / >>Pathways of neurodegeneration - multiple diseases; / >>Shigellosis |
| Function | Catalytic activity:Peptidylproline (omega=180) = peptidylproline (omega=0).,enzyme regulation:Less sensitive to inhibition by cyclosporin A than is CYP-18.,Function:PPIases accelerate the folding of proteins.,Function:PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.,online information:Cyclophilin entry,similarity:Belongs to the cyclophilin-type PPIase family.,similarity:Belongs to the cyclophilin-type PPIase family. PPIase D subfamily.,similarity:Contains 1 PPIase cyclophilin-type domain.,similarity:Contains 3 TPR repeats.,subunit:Binds ESR1.,tissue specificity:Widely expressed., |
