Price range: $268.00 through $328.00
Background:
KAT2A, or GCN5, is a histone acetyltransferase (HAT) that functions primarily as a transcriptional activator. It also functions as a repressor of NF-kappa-B (see MIM 164011) by promoting ubiquitination of the NF-kappa-B subunit RELA (MIM 164014) in a HAT-independent manner (Mao et al., 2009 [PubMed 19339690]).[supplied by OMIM, Sep 2009],
| Target | GCN5 |
| Reactivity | Human, Mouse |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 100kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Modification | |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:20000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#YS0004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Source | |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Purity | |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human GCN5L2. AA range:691-740 |
| Sequence | |
| Specificity | GCN5 Polyclonal Antibody detects endogenous levels of GCN5 protein. |
| Gene Name | KAT2A |
| Protein Name | Histone acetyltransferase KAT2A |
| Other Name | KAT2A; / GCN5; / GCN5L2; / HGCN5; / Histone acetyltransferase KAT2A; / General control of amino acid synthesis protein 5-like 2; / Histone acetyltransferase GCN5; / HsGCN5; / Lysine acetyltransferase 2A; / STAF97 |
| Species | Human |
| Gene ID-1 | 2648 |
| Uniprot | Q92830, |
| Species.1 | Mouse |
| Gene ID-2 | 14534 |
| Uniprot.1 | Q9JHD2 |
| Species.2 | |
| Gene ID-3 | |
| Uniprot.2 | |
| Organism-4 | |
| Gene ID-4 | |
| SwissProt-4 | |
| Background | KAT2A, or GCN5, is a histone acetyltransferase (HAT) that functions primarily as a transcriptional activator. It also functions as a repressor of NF-kappa-B (see MIM 164011) by promoting ubiquitination of the NF-kappa-B subunit RELA (MIM 164014) in a HAT-independent manner (Mao et al., 2009 [PubMed 19339690]).[supplied by OMIM, Sep 2009], |
| Cellular Localization | Nucleus . Chromosome . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Mainly localizes to the nucleus (PubMed:27796307). Also localizes to centrosomes in late G1 and around the G1/S transition, coinciding with the onset of centriole formation (PubMed:27796307). . |
| Tissue Expression | Expressed in all tissues tested. |
| Signaling_pathway | Organismal Systems >> Endocrine system >> Thyroid hormone signaling pathway;Environmental Information Processing >> Signal transduction >> Notch signaling pathway |
| Research Areas | >>Viral life cycle - HIV-1; / >>Notch signaling pathway; / >>Thyroid hormone signaling pathway; / >>Human T-cell leukemia virus 1 infection; / >>Viral carcinogenesis |
| Function | somitogenesis, regionalization, chromatin organization, chromatin remodeling, transcription, transcription, DNA-dependent, regulation of transcription, DNA-dependent, regulation of transcription from RNA polymerase II promoter,transcription from RNA polymerase II promoter, protein amino acid acetylation, pattern specification process,embryonic development ending in birth or egg hatching, anterior/posterior pattern formation, chromatin modification,covalent chromatin modification, histone modification, histone acetylation, histone deubiquitination, protein deubiquitination, RNA biosynthetic process, segmentation, chordate embryonic development, protein amino acid acylation, histone H3 acetylation, regulation of transcription, regulation of RNA metabolic process, chromosome organization, protein modification by small protein removal, protein modification by small protein conjugation or removal, |
| RRID | AB_3714894 |
