Price range: $268.00 through $328.00
Background:
The degree of protein phosphorylation is regulated by a balance of protein kinase and phosphatase activities. Protein phosphatase-1 (PP1; see MIM 176875) is a signal-transducing phosphatase that influences neuronal activity, protein synthesis, metabolism, muscle contraction, and cell division. PPP1R14C is an inhibitor of PP1 (Liu et al., 2002 [PubMed 11812771]).[supplied by OMIM, Feb 2010],
| Size | 50μL/100μL |
| Target | KEPI |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 20kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:20000; Not yet tested in other applications. / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human PPP1R14C. AA range:51-100 |
| Specificity | KEPI Polyclonal Antibody detects endogenous levels of KEPI protein. |
| Gene Name | PPP1R14C |
| Protein Name | Protein phosphatase 1 regulatory subunit 14C |
| Other Name | PPP1R14C; / KEPI; / Protein phosphatase 1 regulatory subunit 14C; / Kinase-enhanced PP1 inhibitor; / PKC-potentiated PP1 inhibitory protein; / Serologically defined breast cancer antigen NY-BR-81 |
| Species | Human |
| Gene ID | 81706 |
| Uniprot | Q8TAE6, |
| Species.1 | Mouse |
| Gene ID.1 | 76142 |
| Uniprot.1 | Q8R4S0, |
| Species.2 | Rat |
| Gene ID.2 | 171010 |
| Uniprot.2 | Q8R4R9 |
| Cellular Localization | Cytoplasm . Membrane; Peripheral membrane protein . |
| Tissue Expression | Detected in breast cancer. |
| Signaling_pathway | |
| Research Areas | |
| Function | Function:Inhibitor of PPP1CA. Has over 600-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction.,similarity:Belongs to the PP1 inhibitor family.,tissue specificity:Detected in breast cancer., |
