SKU: WP12928 Categories: ,

KIR5.1 Polyclonal Antibody

Price range: $268.00 through $328.00

SKU: WP12928-100
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Product details

Background:

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which tends to allow potassium to flow into rather than out of a cell, can form heterodimers with two other inward-rectifier type potassium channels. It may function in fluid and pH balance regulation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2014],

Specifications

Size50μL/100μL
TargetKIR5.1
ReactivityHuman, Mouse, Rat
ApplicationsWB, IHC, IF, ELISA
MW(Calculated)
MW(Observed)48kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:10000; Not yet tested in other applications. / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenThe antiserum was produced against synthesized peptide derived from mouse Kir5.1. AA range:369-418
SpecificityKIR5.1 Polyclonal Antibody detects endogenous levels of KIR5.1 protein.
Gene NameKCNJ16
Protein NameInward rectifier potassium channel 16
Other NameKCNJ16; / Inward rectifier potassium channel 16; / Inward rectifier K; / +; / channel Kir5.1; / Potassium channel; / inwardly rectifying subfamily J member 16
SpeciesHuman
Gene ID16517
UniprotQ9NPI9,
Species.1Mouse
Gene ID.116517
Uniprot.1Q9Z307,
Species.2Rat
Gene ID.2
Uniprot.2P52191
Cellular LocalizationMembrane; Multi-pass membrane protein. Basolateral cell membrane . In kidney distal convoluted tubules, located in the basolateral membrane in the presence of KCNJ10. .
Tissue ExpressionWidely expressed, with highest levels in adult and fetal kidney (at protein level). In the kidney, expressed in the proximal and distal convoluted tubules, but not in glomeruli nor collecting ducts.
Signaling_pathway
Research Areas>>Gastric acid secretion
FunctionFunction:Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ16 may be involved in the regulation of fluid and pH balance.,similarity:Belongs to the inward rectifier-type potassium channel family.,subunit:Seems to form heterodimer with Kir4.1/KCNJ10 or Kir2.1/KCNJ2.,tissue specificity:Highly expressed in kidney, pancreas and thyroid gland.,
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