Price range: $268.00 through $328.00
Background:
This gene encodes a member of a family of proteins containing a ribonucleoprotein (RNP)-type RNA binding motif and a carboxyl-terminal arginine-serine-rich (RS) domain. The encoded protein functions as a pre-mRNA splicing factor. There is a pseudogene for this gene on chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013],
| Size | 50μL/100μL |
| Target | SRp46 |
| Reactivity | Human |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 32kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:40000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human SFRS2B. AA range:31-80 |
| Specificity | SRp46 Polyclonal Antibody detects endogenous levels of SRp46 protein. |
| Gene Name | SRSF8 |
| Protein Name | Serine/arginine-rich splicing factor 8 |
| Other Name | SRSF8; / SFRS2B; / SRP46; / Serine/arginine-rich splicing factor 8; / Pre-mRNA-splicing factor SRP46; / Splicing factor SRp46; / Splicing factor; / arginine/serine-rich 2B |
| Species | Human |
| Gene ID | 10929 |
| Uniprot | Q9BRL6 |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Nucleus . |
| Tissue Expression | Strongly expressed in pancreas, spleen and prostate. Weakly expressed in lung, liver and thymus. |
| Signaling_pathway | |
| Research Areas | >>Spliceosome; / >>Herpes simplex virus 1 infection |
| Function | Function:Invovlved in pre-mRNA alternative splicing.,PTM:Phosphorylated.,similarity:Belongs to the splicing factor SR family.,similarity:Contains 1 RRM (RNA recognition motif) domain.,tissue specificity:Strongly expressed in pancreas, spleen and prostate. Weakly expressed in lung, liver and thymus., |
