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Home/Reagents/Antibody/Primary antibody/Polyclonal Antibody/Rabbit pAb/TANK Polyclonal Antibody
SKU: WP14683 Categories: ,

TANK Polyclonal Antibody

Ucallm_WP14683-50

Price range: $268.00 through $328.00

SKU: WP14683-100
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Product details

Background:

The TRAF (tumor necrosis factor receptor-associated factor) family of proteins associate with and transduce signals from members of the tumor necrosis factor receptor superfamily. The protein encoded by this gene is found in the cytoplasm and can bind to TRAF1, TRAF2, or TRAF3, thereby inhibiting TRAF function by sequestering the TRAFs in a latent state in the cytoplasm. For example, the protein encoded by this gene can block TRAF2 binding to LMP1, the Epstein-Barr virus transforming protein, and inhibit LMP1-mediated NF-kappa-B activation. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010],

Specifications

Size50μL/100μL
TargetTANK
ReactivityHuman, Mouse, Rat
ApplicationsWB, IHC, IF, ELISA
MW(Calculated)
MW(Observed)48kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:10000; Not yet tested in other applications. / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenThe antiserum was produced against synthesized peptide derived from human TANK. AA range:171-220
SpecificityTANK Polyclonal Antibody detects endogenous levels of TANK protein.
Gene NameTANK
Protein NameTRAF family member-associated NF-kappa-B activator
Other NameTANK; / ITRAF; / TRAF2; / TRAF family member-associated NF-kappa-B activator; / TRAF-interacting protein; / I-TRAF
SpeciesHuman
Gene ID10010
UniprotQ92844,
Species.1Mouse
Gene ID.121353
Uniprot.1P70347
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationCytoplasm.
Tissue ExpressionUbiquitous.
Signaling_pathwayCellular Processes >> Transport and catabolism >> Autophagy - animal;Organismal Systems >> Immune system >> NOD-like receptor signaling pathway;Organismal Systems >> Immune system >> RIG-I-like receptor signaling pathway;Human Diseases >> Neurodegenerative disease >> Amyotrophic lateral sclerosis;Human Diseases >> Neurodegenerative disease >> Pathways of neurodegeneration - multiple diseases
Research Areas>>Autophagy - animal; / >>NOD-like receptor signaling pathway; / >>RIG-I-like receptor signaling pathway; / >>Amyotrophic lateral sclerosis; / >>Pathways of neurodegeneration - multiple diseases; / >>Lipid and atherosclerosis
FunctionFunction:Acts as a regulator of TRAF function by maintaining them in a latent state. Overexpression inhibits TRAF2-mediated NF-kappa-B activation signaled by CD40, TNFR1 and TNFR2. Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. May be involved in I-kappa-B-kinase (IKK) regulation; may function as an adapter for kinases such as TBK1 or IKBKE that can modulate IKK activity.,PTM:Phosphorylated by IKBKE.,similarity:Contains 1 C2H2-type zinc finger.,subunit:Interacts with TBK1 (via TRAF-C domain). Interacts with TRAF1 (via TRAF-C domain). Interacts with TRAF2 (via TRAF-C domain); the interaction is disrupted by the phosphorylation of TANK by IKBKE. Interacts with TRAF3 (via TRAF-C domain); the interaction with TRAF3 is weaker than the interactions with TRAF1 and TRAF3. Interacts with IKBKG; the interaction is enhanced by IKBKE and TBK1. Part of a ternary complex consisting of TANK, IKBKB and IKBKG.,tissue specificity:Ubiquitous.,
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