Name: ZO-2 Polyclonal Antibody
SKU: WP15098
Price: 268 USD
Availability: InStock

ZO-2 Polyclonal Antibody

Ucallm_WP15098-50

Price range: $268.00 through $328.00

Size

100μl

50μl

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SKU: WP15098-100

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Product details

Background:

This gene encodes a zonula occluden that is a member of the membrane-associated guanylate kinase homolog family. The encoded protein functions as a component of the tight junction barrier in epithelial and endothelial cells and is necessary for proper assembly of tight junctions. Mutations in this gene have been identified in patients with hypercholanemia, and genomic duplication of a 270 kb region including this gene causes autosomal dominant deafness-51. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011],

Specifications

Size	50μL/100μL
Target	ZO-2
Reactivity	Human, Mouse, Rat
Applications	WB, ELISA
MW(Calculated)
MW(Observed)	160kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-1:2000; ELISA 1:10000; Not yet tested in other applications.
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	The antiserum was produced against synthesized peptide derived from human ZO-2. AA range:1063-1112
Specificity	ZO-2 Polyclonal Antibody detects endogenous levels of ZO-2 protein.
Gene Name	TJP2
Protein Name	Tight junction protein ZO-2
Other Name	TJP2; / X104; / ZO2; / Tight junction protein ZO-2; / Tight junction protein 2; / Zona occludens protein 2; / Zonula occludens protein 2
Species	Human
Gene ID	9414
Uniprot	Q9UDY2,
Species.1	Mouse
Gene ID.1	21873
Uniprot.1	Q9Z0U1
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Cell junction, adherens junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side . Cell junction, tight junction . Nucleus . Also nuclear under environmental stress conditions and in migratory endothelial cells and subconfluent epithelial cell cultures. .
Tissue Expression	This protein is found in epithelial cell junctions. Isoform A1 is abundant in the heart and brain. Detected in brain and skeletal muscle. It is present almost exclusively in normal tissues. Isoform C1 is expressed at high level in the kidney, pancreas, heart and placenta. Not detected in brain and skeletal muscle. Found in normal as well as in most neoplastic tissues.
Signaling_pathway	Cellular Processes >> Cellular community - eukaryotes >> Tight junction
Research Areas	>>Tight junction; / >>Vibrio cholerae infection
Function	Disease:Defects in TJP2 are involved in familial hypercholanemia (FHCA) [MIM:607748]. FHCA is a disorder characterized by elevated serum bile acid concentrations, itching, and fat malabsorption.,Function:Plays a role in tight junctions and adherens junctions.,similarity:Belongs to the MAGUK family.,similarity:Contains 1 guanylate kinase-like domain.,similarity:Contains 1 SH3 domain.,similarity:Contains 3 PDZ (DHR) domains.,subcellular location:Also nuclear under environmental stress conditions and in migratory endothelial cells and subconfluent epithelial cell cultures.,subunit:Homodimer, and heterodimer with ZO1. Interacts with occludin, SAFB and UBN1. Interaction with SAFB occurs in the nucleus.,tissue specificity:This protein is found in epithelial cell junctions. Isoform A1 is abundant in the heart and brain whereas isoform C1 is expressed at high level in the kidney, pancreas, heart and placenta. In brain and skeletal muscle, only isoform A1 is detectable. Isoform C1 is found in normal as well as in most neoplastic tissues while isoform A1 is present almost exclusively in normal tissue.,