Name: ADM Polyclonal Antibody
SKU: WP15278
Price: 268 USD
Availability: InStock

ADM Polyclonal Antibody

Ucallm_WP15278-50

Price range: $268.00 through $328.00

Size

100μl

50μl

Clear

SKU: WP15278-100

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Product details

Background:

The protein encoded by this gene is a preprohormone which is cleaved to form two biologically active peptides, adrenomedullin and proadrenomedullin N-terminal 20 peptide. Adrenomedullin is a 52 aa peptide with several functions, including vasodilation, regulation of hormone secretion, promotion of angiogenesis, and antimicrobial activity. The antimicrobial activity is antibacterial, as the peptide has been shown to kill E. coli and S. aureus at low concentration. [provided by RefSeq, Aug 2014],

Specifications

Size	50μL/100μL
Target	ADM
Reactivity	Human, Rat
Applications	WB, IHC, IF, ELISA
MW(Calculated)
MW(Observed)	20kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-1:2000; IHC: 1:100-300; ELISA 1:20000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	The antiserum was produced against synthesized peptide derived from the Internal region of human ADM. AA range:101-150
Specificity	ADM Polyclonal Antibody detects endogenous levels of ADM protein.
Gene Name	ADM
Protein Name	ADM
Other Name	ADM; / AM; / ADM
Species	Human
Gene ID	133
Uniprot	P35318,
Species.1
Gene ID.1
Uniprot.1
Species.2	Rat
Gene ID.2	25026
Uniprot.2	P43145
Cellular Localization	Secreted.
Tissue Expression	Highest levels found in pheochromocytoma and adrenal medulla. Also found in lung, ventricle and kidney tissues.
Signaling_pathway	Organismal Systems >> Circulatory system >> Vascular smooth muscle contraction
Research Areas	>>Neuroactive ligand-receptor interaction; / >>Vascular smooth muscle contraction
Function	Function:AM and PAMP are potent hypotensive and vasodilatator agents. Numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis. In the kidney, am is diuretic and natriuretic, and both am and pamp inhibit aldosterone secretion by direct adrenal actions. In pituitary gland, both peptides at physiologically relevant doses inhibit basal ACTH secretion. Both peptides appear to act in brain and pituitary gland to facilitate the loss of plasma volume, actions which complement their hypotensive effects in blood vessels.,similarity:Belongs to the adrenomedullin family.,tissue specificity:Highest levels found in pheochromocytoma and adrenal medulla. Also found in lung, ventricle and kidney tissues.,