Price range: $268.00 through $328.00
Background:
This gene encodes a cytokine receptor that belongs to the interleukin-1 receptor family. The encoded protein is a receptor for interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist. It is an important mediator involved in many cytokine-induced immune and inflammatory responses. This gene is located in a cluster of related cytokine receptor genes on chromosome 2q12. [provided by RefSeq, Dec 2013],
| Size | 50μL/100μL |
| Target | IL-1RI |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 75kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC: 1:100-300; ELISA 1:20000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from the N-terminal region of human IL1R1. AA range:31-80 |
| Specificity | IL-1RI Polyclonal Antibody detects endogenous levels of IL-1RI protein. |
| Gene Name | IL1R1 |
| Protein Name | Interleukin-1 receptor type 1 |
| Other Name | IL1R1; / IL1R; / IL1RA; / IL1RT1; / Interleukin-1 receptor type 1; / IL-1R-1; / IL-1RT-1; / IL-1RT1; / CD121 antigen-like family member A; / Interleukin-1 receptor alpha; / IL-1R-alpha; / Interleukin-1 receptor type I; / p80; / CD121a |
| Species | Human |
| Gene ID | 3554 |
| Uniprot | P14778, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | P13504 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Membrane; Single-pass type I membrane protein . Cell membrane . Secreted . |
| Tissue Expression | Expressed in T-helper cell subsets. Preferentially expressed in T-helper 1 (Th1) cells. |
| Signaling_pathway | Organismal Systems >> Immune system >> Hematopoietic cell lineage;Organismal Systems >> Immune system >> Th17 cell differentiation;Organismal Systems >> Sensory system >> Inflammatory mediator regulation of TRP channels;Organismal Systems >> Development and regeneration >> Osteoclast differentiation;Environmental Information Processing >> Signal transduction >> MAPK signaling pathway;Environmental Information Processing >> Signal transduction >> NF-kappa B signaling pathway;Environmental Information Processing >> Signaling molecules and interaction >> Cytokine-cytokine receptor interaction |
| Research Areas | >>MAPK signaling pathway; / >>Cytokine-cytokine receptor interaction; / >>NF-kappa B signaling pathway; / >>Osteoclast differentiation; / >>Hematopoietic cell lineage; / >>Th17 cell differentiation; / >>Inflammatory mediator regulation of TRP channels; / >>Pathogenic Escherichia coli infection; / >>Shigellosis; / >>Amoebiasis; / >>Human cytomegalovirus infection; / >>Human T-cell leukemia virus 1 infection; / >>Fluid shear stress and atherosclerosis |
| Function | Function:Receptor for interleukin-1 alpha (IL-1A), beta (IL-1B), and interleukin-1 receptor antagonist protein (IL-1RA). Binding to the agonist leads to the activation of NF-kappa-B. Signaling involves formation of a ternary complex containing IL1RAP, TOLLIP, MYD88, and IRAK1 or IRAK2.,similarity:Belongs to the interleukin-1 receptor family.,similarity:Contains 1 TIR domain.,similarity:Contains 3 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Binds IL1RAP., |
