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Background:
The protein encoded by this gene is a fructose transporter responsible for fructose uptake by the small intestine. The encoded protein also is necessary for the increase in blood pressure due to high dietary fructose consumption. [provided by RefSeq, Jun 2016],
| Size | 50μL/100μL |
| Target | Glut5 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 55kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; ELISA 1:20000; Not yet tested in other applications. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from the N-terminal region of human SLC2A5. AA range:31-80 |
| Specificity | Glut5 Polyclonal Antibody detects endogenous levels of Glut5 protein. |
| Gene Name | SLC2A5 |
| Protein Name | Solute carrier family 2 facilitated glucose transporter member 5 |
| Other Name | SLC2A5; / GLUT5; / Solute carrier family 2, facilitated glucose transporter member 5; / Fructose transporter; / Glucose transporter type 5, small intestine; / GLUT-5 |
| Species | Human |
| Gene ID | 6518 |
| Uniprot | P22732, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q9WV38 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Apical cell membrane; Multi-pass membrane protein . Cell membrane; Multi-pass membrane protein . Cell membrane, sarcolemma . Localized on the apical membrane of jejunum villi, but also on lateral plasma membranes of the villi. Transport to the cell membrane is dependent on RAB11A. . |
| Tissue Expression | Detected in skeletal muscle, and in jejunum brush border membrane and basolateral membrane (at protein level) (PubMed:7619085). Expressed in small intestine, and at much lower levels in kidney, skeletal muscle, and adipose tissue. |
| Signaling_pathway | |
| Research Areas | >>Carbohydrate digestion and absorption |
| Function | Function:Cytochalasin B-sensitive carrier. Seems to function primarily as a fructose transporter.,induction:By forskolin (in Caco-2 cells).,mass spectrometry: PubMed:11840567,similarity:Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.,tissue specificity:Expressed in small intestine, and at much lower levels in kidney, skeletal muscle, and adipose tissue., |
