Product details

Background:

This gene encodes a voltage-dependent anion channel protein that is a major component of the outer mitochondrial membrane. The encoded protein facilitates the exchange of metabolites and ions across the outer mitochondrial membrane and may regulate mitochondrial functions. This protein also forms channels in the plasma membrane and may be involved in transmembrane electron transport. Alternate splicing results in multiple transcript variants. Multiple pseudogenes of this gene are found on chromosomes 1, 2 3, 6, 9, 12, X and Y.[provided by RefSeq, Sep 2010],

Specifications

Size	50μL/100μL
Target	VDAC1
Reactivity	Human, Mouse, Rat
Applications	WB, ELISA
MW(Calculated)
MW(Observed)	31kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-1:2000; ELISA 1:20000; Not yet tested in other applications.
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	The antiserum was produced against synthesized peptide derived from the N-terminal region of human VDAC1. AA range:1-50
Specificity	VDAC1 Polyclonal Antibody detects endogenous levels of VDAC1 protein.
Gene Name	VDAC1
Protein Name	Voltage-dependent anion-selective channel protein 1
Other Name	VDAC1; / VDAC; / Voltage-dependent anion-selective channel protein 1; / VDAC-1; / hVDAC1; / Outer mitochondrial membrane protein porin 1; / Plasmalemmal porin; / Porin 31HL; / Porin 31HM
Species	Human
Gene ID	7416
Uniprot	P21796,
Species.1	Mouse
Gene ID.1	22333
Uniprot.1	Q60932,
Species.2	Rat
Gene ID.2	83529
Uniprot.2	Q9Z2L0
Cellular Localization	Mitochondrion outer membrane; Multi-pass membrane protein . Cell membrane; Multi-pass membrane protein . Membrane raft; Multi-pass membrane protein .
Tissue Expression	Expressed in erythrocytes (at protein level) (PubMed:27641616). Expressed in heart, liver and skeletal muscle (PubMed:8420959).
Signaling_pathway	Cellular Processes >> Cell growth and death >> Necroptosis;Cellular Processes >> Cell growth and death >> Cellular senescence;Organismal Systems >> Immune system >> Neutrophil extracellular trap formation;Organismal Systems >> Immune system >> NOD-like receptor signaling pathway;Human Diseases >> Neurodegenerative disease >> Alzheimer disease;Human Diseases >> Neurodegenerative disease >> Parkinson disease;Human Diseases >> Neurodegenerative disease >> Amyotrophic lateral sclerosis;Human Diseases >> Neurodegenerative disease >> Huntington disease;Human Diseases >> Neurodegenerative disease >> Spinocerebellar ataxia;Human Diseases >> Neurodegenerative disease >> Prion disease;Human Diseases >> Neurodegenerative disease >> Pathways of neurodegeneration - multiple diseases;Environmental Information Processing >> Signal transduction >> Calcium signaling pathway;Environmental Information Processing >> Signal transduction >> cGMP-PKG signaling pathway
Research Areas	>>Calcium signaling pathway; / >>cGMP-PKG signaling pathway; / >>Necroptosis; / >>Cellular senescence; / >>Neutrophil extracellular trap formation; / >>NOD-like receptor signaling pathway; / >>Cholesterol metabolism; / >>Alzheimer disease; / >>Parkinson disease; / >>Amyotrophic lateral sclerosis; / >>Huntington disease; / >>Spinocerebellar ataxia; / >>Prion disease; / >>Pathways of neurodegeneration - multiple diseases; / >>Shigellosis; / >>Influenza A; / >>Human T-cell leukemia virus 1 infection; / >>Chemical carcinogenesis - reactive oxygen species; / >>Diabetic cardiomyopathy
Function	Domain:Consists mainly of a membrane-spanning beta-barrel formed by 19 beta-strands. The helical N-terminus folds back into the pore opening and plays a role in voltage-gated channel activity.,Function:Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis.,similarity:Belongs to the eukaryotic mitochondrial porin family.,subunit:Interacts with hexokinases (By similarity). Interacts with BCL2L1. Interacts with influenza A virus PB1-F2 protein.,tissue specificity:Heart, liver and skeletal muscle.,

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VDAC1 Polyclonal Antibody

Product details

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VDAC1 Polyclonal Antibody

Product details

Specifications

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