Product details
Background:
CCHCR rabbit pAb
Ucallm_WP16296-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | CCHCR |
| Reactivity | Human, Mouse |
| Applications | WB |
| MW(Calculated) | 86kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human CCHCR AA range: 180-230 |
| Specificity | This antibody detects endogenous levels of CCHCR at Human/Mouse |
| Gene Name | CCHCR1 C6orf18 HCR |
| Protein Name | CCHCR |
| Other Name | |
| Species | Human |
| Gene ID | 54535 |
| Uniprot | Q8TD31, |
| Species.1 | Mouse |
| Gene ID.1 | 240084 |
| Uniprot.1 | Q8K2I2 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasm. Nucleus. |
| Tissue Expression | Found in all tissues tested, abundantly expressed in heart, liver, skeletal muscle, kidney and pancreas, and to a lesser extent in lung and placenta. Overexpressed in keratinocytes of psoriatic lesions. |
| Signaling_pathway | |
| Research Areas | |
| Function | Function:May be a regulator of keratinocyte proliferation or differentiation.,polymorphism:HCR*WWCC is associated with susceptibility to psoriasis. Psoriasis is a chronic inflammatory dermatosis that affects approximately 2% of the population. It is a multifactorial disease characterized by red, scaly skin lesions that are usually found on the scalp, elbows, and knees, and may be associated with severe arthritis. The lesions are caused by hyperproliferative keratinocytes and infiltration of inflammatory cells into the dermis and epidermis. The usual age of onset of psoriasis is between 15 and 30 years, although it can present at any age. Association of HCR with psoriasis seem to be due to linkage disequilibrium with CW*0602 (PubMed:11348465). HCR is unlikely to be directly involved in psoriasis development.,tissue specificity:Found in all tissues tested, abundantly expressed in heart, liver, skeletal muscle, kidney and pancreas, and to a lesser extent in lung and placenta. Overexpressed in keratinocytes of psoriatic lesions., |
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