Price range: $268.00 through $328.00
Background:
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member can efficiently reduce aliphatic and aromatic aldehydes, and it is less active on hexoses. It is highly expressed in adrenal gland, small intestine, and colon, and may play an important role in liver carcinogenesis. [provided by RefSeq, Jul 2008],
| Size | 50μL/100μL |
| Target | AK1BA |
| Reactivity | Human |
| Applications | WB |
| MW(Calculated) | 35kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human AK1BA AA range: 124-174 |
| Specificity | This antibody detects endogenous levels of AK1BA at Human |
| Gene Name | AKR1B10 AKR1B11 |
| Protein Name | AK1BA |
| Other Name | |
| Species | Human |
| Gene ID | 57016 |
| Uniprot | O60218 |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Lysosome . Secreted . Secreted through a lysosome-mediated non-classical pathway. |
| Tissue Expression | Found in many tissues. Highly expressed in small intestine, colon and adrenal gland. |
| Signaling_pathway | |
| Research Areas | >>Pentose and glucuronate interconversions; / >>Fructose and mannose metabolism; / >>Galactose metabolism; / >>Glycerolipid metabolism; / >>Folate biosynthesis; / >>Metabolic pathways |
| Function | enzyme regulation:Inhibited by tolrestat.,Function:Acts as all-trans-retinaldehyde reductase. Can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). May be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs.,similarity:Belongs to the aldo/keto reductase family.,tissue specificity:Found in many tissues. Highly expressed in small intestine, colon and adrenal gland., |
