Product details
Background:
IYD rabbit pAb
Ucallm_WP6866-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | IYD |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 32kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human IYD |
| Specificity | This antibody detects endogenous levels of IYD at Human, Mouse,Rat |
| Gene Name | IYD C6orf71 DEHAL1 |
| Protein Name | Iodotyrosine dehalogenase 1 (IYD-1) (EC 1.22.1.1) |
| Other Name | |
| Species | Human |
| Gene ID | 389434 |
| Uniprot | Q6PHW0, |
| Species.1 | Mouse |
| Gene ID.1 | 70337 |
| Uniprot.1 | Q9DCX8, |
| Species.2 | Rat |
| Gene ID.2 | 308129 |
| Uniprot.2 | Q5BK17 |
| Cellular Localization | Cell membrane; Single-pass membrane protein . Cytoplasmic vesicle membrane . |
| Tissue Expression | Expressed at a high level in thyroid gland (at protein level). Expressed at a high level in thyroid gland and at lower level in kidney and trachea. |
| Signaling_pathway | |
| Research Areas | |
| Function | Catalyzes the dehalogenation of halotyrosines such as 3-bromo-L-tyrosine, 3-chloro-L-tyrosine, 3-iodo-L-tyrosine and 3,5-diiodo-L-tyrosine . During thyroid hormone biosynthesis, facilitates iodide salvage by catalysing the oxidative NADPH-dependent deiodination of the halogenated by-products of thyroid hormone production, monoiodotyrosine (L-MIT) and diiodotyrosine (L-DIT) . The scavanged iodide can then reenter the hormone-producing pathways . Acts more efficiently on 3-iodo-L-tyrosine than 3,5-diiodo-L-tyrosine . |
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