SKU: WP17718 Categories: ,

Syntenin-2 rabbit pAb

Price range: $268.00 through $328.00

SKU: WP17718-100
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Product details

Background:

syndecan binding protein(SDCBP) Homo sapiens The protein encoded by this gene was initially identified as a molecule linking syndecan-mediated signaling to the cytoskeleton. The syntenin protein contains tandemly repeated PDZ domains that bind the cytoplasmic, C-terminal domains of a variety of transmembrane proteins. This protein may also affect cytoskeletal-membrane organization, cell adhesion, protein trafficking, and the activation of transcription factors. The protein is primarily localized to membrane-associated adherens junctions and focal adhesions but is also found at the endoplasmic reticulum and nucleus. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008],

Specifications

Size50μL/100μL
TargetSyntenin-2
ReactivityHuman, Rat, Dog, Pig
ApplicationsWB, ELISA
MW(Calculated)33kD
MW(Observed)
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:1000-2000; ELISA 1:5000-20000
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from human Syntenin-2 AA range: 71-120
SpecificityThis antibody detects endogenous levels of Human,Rat,Dog,Pig Syntenin-2
Gene NameSDCBP2 SITAC18
Protein NameSyntenin-2 (Syndecan-binding protein 2)
Other NameSyndecan-binding protein 2
SpeciesHuman
Gene ID6386
UniprotQ9H190,
Species.1Mouse
Gene ID.1228765
Uniprot.1Q99JZ0
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationCytoplasm . Nucleus, nucleolus . Nucleus, nucleoplasm . Cell membrane . Nucleus speckle . Associates with intracellular membranes and enriched in the apical region of the cell and in intracellular compartments (PubMed:11102519). Colocalizes with TM4SF1 in the apical region of the cell (PubMed:11102519). Predominantly targeted to nuclear PIP2 pools. Shuttles between several subcellular compartments (PubMed:15961997). PIP2 plays an important role in the distribution of SDCBP2 (PubMed:23300061). .
Tissue ExpressionPreferentially expressed in cells of the digestive tract (PubMed:11102519). Low expression in skeletal muscle and kidney (PubMed:11102519). Detected in differentiated keratinocytes of normal and malignant epithelium (PubMed:22623796). In healthy skin, expression is localized in suprabasal epidermal layers (PubMed:22623796).
Signaling_pathway
Research Areas
FunctionBinds phosphatidylinositol 4,5-bisphosphate (PIP2). May play a role in the organization of nuclear PIP2, cell division and cell survival .
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