Syntenin-2 rabbit pAb
Ucallm_WP17718-50
Price range: $268.00 through $328.00
Product details
Background:
syndecan binding protein(SDCBP) Homo sapiens The protein encoded by this gene was initially identified as a molecule linking syndecan-mediated signaling to the cytoskeleton. The syntenin protein contains tandemly repeated PDZ domains that bind the cytoplasmic, C-terminal domains of a variety of transmembrane proteins. This protein may also affect cytoskeletal-membrane organization, cell adhesion, protein trafficking, and the activation of transcription factors. The protein is primarily localized to membrane-associated adherens junctions and focal adhesions but is also found at the endoplasmic reticulum and nucleus. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008],
Specifications
| Size | 50μL/100μL |
| Target | Syntenin-2 |
| Reactivity | Human, Rat, Dog, Pig |
| Applications | WB, ELISA |
| MW(Calculated) | 33kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:1000-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human Syntenin-2 AA range: 71-120 |
| Specificity | This antibody detects endogenous levels of Human,Rat,Dog,Pig Syntenin-2 |
| Gene Name | SDCBP2 SITAC18 |
| Protein Name | Syntenin-2 (Syndecan-binding protein 2) |
| Other Name | Syndecan-binding protein 2 |
| Species | Human |
| Gene ID | 6386 |
| Uniprot | Q9H190, |
| Species.1 | Mouse |
| Gene ID.1 | 228765 |
| Uniprot.1 | Q99JZ0 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasm . Nucleus, nucleolus . Nucleus, nucleoplasm . Cell membrane . Nucleus speckle . Associates with intracellular membranes and enriched in the apical region of the cell and in intracellular compartments (PubMed:11102519). Colocalizes with TM4SF1 in the apical region of the cell (PubMed:11102519). Predominantly targeted to nuclear PIP2 pools. Shuttles between several subcellular compartments (PubMed:15961997). PIP2 plays an important role in the distribution of SDCBP2 (PubMed:23300061). . |
| Tissue Expression | Preferentially expressed in cells of the digestive tract (PubMed:11102519). Low expression in skeletal muscle and kidney (PubMed:11102519). Detected in differentiated keratinocytes of normal and malignant epithelium (PubMed:22623796). In healthy skin, expression is localized in suprabasal epidermal layers (PubMed:22623796). |
| Signaling_pathway | |
| Research Areas | |
| Function | Binds phosphatidylinositol 4,5-bisphosphate (PIP2). May play a role in the organization of nuclear PIP2, cell division and cell survival . |
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