Product details
Background:
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DLDH rabbit pAb
Ucallm_WP17939-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | DLD |
| Reactivity | Human, Mouse, Rat |
| Applications | IHC, WB |
| MW(Calculated) | 56kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; IHC 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human C-ternal DLDH |
| Specificity | This antibody detects endogenous levels of DLDH at Human, Mouse,Rat |
| Gene Name | DLD GCSL LAD PHE3 |
| Protein Name | Dihydrolipoyl dehydrogenase, mitochondrial (Dihydrolipoamide dehydrogenase) (Glycine cleavage system L protein) |
| Other Name | Dihydrolipoyl dehydrogenase, mitochondrial; / Dihydrolipoamide dehydrogenase; / Glycine cleavage system L protein |
| Species | Human |
| Gene ID | 1738 |
| Uniprot | P09622, |
| Species.1 | Mouse |
| Gene ID.1 | 13382 |
| Uniprot.1 | O08749, |
| Species.2 | Rat |
| Gene ID.2 | 298942 |
| Uniprot.2 | Q6P6R2 |
| Cellular Localization | Mitochondrion matrix . Nucleus . Cell projection, cilium, flagellum . Cytoplasmic vesicle, secretory vesicle, acrosome . Mainly localizes in the mitochondrion. A small fraction localizes to the nucleus, where the 2-oxoglutarate dehydrogenase complex is required for histone succinylation. . |
| Tissue Expression | |
| Signaling_pathway | |
| Research Areas | |
| Function | Lipoamide dehydrogenase is a component of the glycine cleavage system as well as an E3 component of three alpha-ketoacid dehydrogenase complexes (pyruvate-, alpha-ketoglutarate-, and branched-chain amino acid-dehydrogenase complex) . The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion . A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A . In monomeric form may have additional moonlighting function as serine protease . Involved in the hyperactivation of spermatazoa during capacitation and in the spermatazoal acrosome reaction (By similarity). |
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