Anti-BRG1 Rabbit Monoclonal Antibody

Background：The protein encoded by this gene is a member ofThe SWI/SNF family of proteins and is similar toThe brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by alteringThe chromatin structure around those genes.The encoded protein is part ofThe large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. In addition, this protein can bind BRCA1, as well as regulateThe expression ofThe tumorigenic protein CD44. Mutations in this gene cause rhabdoid tumor predisposition syndrome type 2. Multiple transcript variants encoding different isoforms have been found for this gene.

Looking for a robust Anti-BRG1 Rabbit Monoclonal Antibody for SWI/SNF chromatin remodeling, BRCA1 interaction, or rhabdoid tumor research? Our WR4073 antibody delivers reliable results: validated across 14+ human/mouse/rat cell lines (HL60, HUVEC, HCT116 & more), optimized for 4-20% SDS-PAGE, and usable at a cost-efficient 1:5000 dilution (incubated 4°C overnight, detected via Dylight 800-conjugated secondary antibody). Critically, it detects the 220 kDa observed band (vs. 185 kDa predicted)—ideal for studying BRG1’s post-translational modifications (key to its chromatin and cancer-related functions).

Search “Anti-BRG1 Rabbit Monoclonal Antibody WR4073” or “BRG1 antibody for SWI/SNF chromatin remodeling research” to access our product page: grab technical documents, request a sample, or order your batch of WR4073 to advance your BRG1-focused experiments today!