OPTN Rabbit Monoclonal Antibody

Background：This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein.

Elevate your ophthalmic disease and cellular biology research with the OPTN Rabbit Monoclonal Antibody (WR4104)—a Google-optimized, rigorously validated tool for specific optineurin detection. Tested across 14+ human, mouse, and rat cell lines (HL60, HCT116, A549, etc.), this antibody delivers clear, reliable banding (63 kDa predicted / 74 kDa observed) via 4-20% SDS-PAGE, paired with optimized conditions (4°C overnight incubation, 1:2500 dilution) and a robust Dylight 800-conjugated Goat anti-Rabbit detection system.

Ideal for studying OPTN’s roles in glaucoma (normal-tension and primary open angle glaucoma), TNF-α/Fas-ligand mediated apoptosis/inflammation, vesicle trafficking (RAB8 interaction), or protein-protein interactions (huntingtin, transcription factor IIIA), this trusted OPTN Rabbit Monoclonal Antibody boosts assay reproducibility. Order WR4104 today to advance your OPTN-focused experiments with a SEO-verified, high-performance research tool tailored for ophthalmic disease, cell signaling, and membrane trafficking studies.