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Home/Reagents/Antibody/Primary antibody/Polyclonal Antibody/Rabbit pAb/α-E-Catenin (Phospho Ser652) rabbit pAb
SKU: WP10548 Categories: ,

α-E-Catenin (Phospho Ser652) rabbit pAb

Ucallm_WP10548-50

Price range: $288.00 through $368.00

SKU: WP10548-100
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Product details

Background:

catenin alpha 1(CTNNA1) Homo sapiens This gene encodes a member of the catenin family of proteins that play an important role in cell adhesion process by connecting cadherins located on the plasma membrane to the actin filaments inside the cell. The encoded mechanosensing protein contains three vinculin homology domains and undergoes conformational changes in response to cytoskeletal tension, resulting in the reconfiguration of cadherin-actin filament connections. Certain mutations in this gene cause butterfly-shaped pigment dystrophy. [provided by RefSeq, May 2016],

Specifications

Size50μL/100μL
TargetCatenin-α1 Phospho Ser652
ReactivityHuman, Mouse, Rat
ApplicationsWB
MW(Calculated)
MW(Observed)100kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/Modificationphosphate
Recommended Dilution RatioWB 1:1000-2000
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized phosho peptide around human α-E-Catenin (Ser652)
SpecificityThis antibody detects endogenous levels of Human Mouse Rat α-E-Catenin (phospho-Ser652)
Gene NameCTNNA1
Protein NameCatenin alpha-1 (Ser652)
Other NameCTNNA1; / Catenin alpha-1; / Alpha E-catenin; / Cadherin-associated protein; / Renal carcinoma antigen NY-REN-13
SpeciesHuman
Gene ID1495
UniprotP35221,
Species.1Mouse
Gene ID.112385
Uniprot.1P26231
Species.2
Gene ID.2
Uniprot.2
Cellular Localization[Isoform 1]: Cytoplasm, cytoskeleton. Cell junction, adherens junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction. Found at cell-cell boundaries and probably at cell-matrix boundaries.; [Isoform 3]: Cell membrane; Peripheral membrane protein; Cytoplasmic side .
Tissue ExpressionExpressed ubiquitously in normal tissues.
Signaling_pathwayCellular Processes >> Cellular community - eukaryotes >> Adherens junction;Organismal Systems >> Immune system >> Leukocyte transendothelial migration;Human Diseases >> Cancer: overview >> Pathways in cancer;Human Diseases >> Cancer: specific types >> Gastric cancer;Human Diseases >> Cancer: specific types >> Endometrial cancer;Environmental Information Processing >> Signal transduction >> Hippo signaling pathway
Research Areas>>Hippo signaling pathway; / >>Adherens junction; / >>Leukocyte transendothelial migration; / >>Bacterial invasion of epithelial cells; / >>Pathways in cancer; / >>Endometrial cancer; / >>Gastric cancer; / >>Arrhythmogenic right ventricular cardiomyopathy
FunctionDisease:Abnormalities of alpha-catenin are involved in the process of cancer invasion and metastasis.,Function:Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. May play a crucial role in cell differentiation.,PTM:Sumoylated.,similarity:Belongs to the vinculin/alpha-catenin family.,subcellular location:Found at cell-cell boundaries and probably at cell-matrix boundaries.,subunit:Binds MLLT4 and F-actin (By similarity). Interacts directly with PSEN1 and CTNNB1 to form part of the PSEN1/cadherin/catenin adhesion complex. Interacts with ARHGAP21 and with JUB.,tissue specificity:Expressed ubiquitously in normal tissues.,
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