α-E-Catenin (Phospho Ser652) rabbit pAb
Ucallm_WP10548-50
Price range: $288.00 through $368.00
Product details
Background:
catenin alpha 1(CTNNA1) Homo sapiens This gene encodes a member of the catenin family of proteins that play an important role in cell adhesion process by connecting cadherins located on the plasma membrane to the actin filaments inside the cell. The encoded mechanosensing protein contains three vinculin homology domains and undergoes conformational changes in response to cytoskeletal tension, resulting in the reconfiguration of cadherin-actin filament connections. Certain mutations in this gene cause butterfly-shaped pigment dystrophy. [provided by RefSeq, May 2016],
Specifications
| Size | 50μL/100μL |
| Target | Catenin-α1 Phospho Ser652 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | |
| MW(Observed) | 100kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | phosphate |
| Recommended Dilution Ratio | WB 1:1000-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized phosho peptide around human α-E-Catenin (Ser652) |
| Specificity | This antibody detects endogenous levels of Human Mouse Rat α-E-Catenin (phospho-Ser652) |
| Gene Name | CTNNA1 |
| Protein Name | Catenin alpha-1 (Ser652) |
| Other Name | CTNNA1; / Catenin alpha-1; / Alpha E-catenin; / Cadherin-associated protein; / Renal carcinoma antigen NY-REN-13 |
| Species | Human |
| Gene ID | 1495 |
| Uniprot | P35221, |
| Species.1 | Mouse |
| Gene ID.1 | 12385 |
| Uniprot.1 | P26231 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | [Isoform 1]: Cytoplasm, cytoskeleton. Cell junction, adherens junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction. Found at cell-cell boundaries and probably at cell-matrix boundaries.; [Isoform 3]: Cell membrane; Peripheral membrane protein; Cytoplasmic side . |
| Tissue Expression | Expressed ubiquitously in normal tissues. |
| Signaling_pathway | Cellular Processes >> Cellular community - eukaryotes >> Adherens junction;Organismal Systems >> Immune system >> Leukocyte transendothelial migration;Human Diseases >> Cancer: overview >> Pathways in cancer;Human Diseases >> Cancer: specific types >> Gastric cancer;Human Diseases >> Cancer: specific types >> Endometrial cancer;Environmental Information Processing >> Signal transduction >> Hippo signaling pathway |
| Research Areas | >>Hippo signaling pathway; / >>Adherens junction; / >>Leukocyte transendothelial migration; / >>Bacterial invasion of epithelial cells; / >>Pathways in cancer; / >>Endometrial cancer; / >>Gastric cancer; / >>Arrhythmogenic right ventricular cardiomyopathy |
| Function | Disease:Abnormalities of alpha-catenin are involved in the process of cancer invasion and metastasis.,Function:Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. May play a crucial role in cell differentiation.,PTM:Sumoylated.,similarity:Belongs to the vinculin/alpha-catenin family.,subcellular location:Found at cell-cell boundaries and probably at cell-matrix boundaries.,subunit:Binds MLLT4 and F-actin (By similarity). Interacts directly with PSEN1 and CTNNB1 to form part of the PSEN1/cadherin/catenin adhesion complex. Interacts with ARHGAP21 and with JUB.,tissue specificity:Expressed ubiquitously in normal tissues., |
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