$999.00
β-hydroxybutyryllysine Specific Antibody Conjugated Agarose Beads is an immunoaffinity enrichment tool for β-hydroxybutyryl lysine peptides in mass spectrometry-based proteomics. The highly specific antibody selectively captures target modified peptides without cross-reactivity, is applicable to all species, efficiently enriches low-abundance peptides and reduces background interference, delivering stable and reliable results for β-hydroxybutyryl lysine modification research.
| Target | β-Hydroxybutyryllysine |
| Reactivity | Species Independent |
| Application | IAC |
| MW(Calculated) | |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | |
| Conjugate | Agarose Beads |
| Modification | Lysine β-Hydroxybutyrylation |
| Modified site | Lys（K） |
| Recommended dilution ratio | |
| Composition | 50/250 μL settled agarose beads supplied as 50% slurry, containing 66% glycerol |
| Purification process | |
| Purity | |
| Storage | Store at-20°C and avoid freezing. |
| Stability | Stable for 12 months from date of receipt |
| Clonal | Monoclonal |
| Clone Number | |
| Immunogen | |
| Sequence | |
| Specificity | |
| Gene name | |
| Protein Name | |
| Alternative name | Kbhb |
| Organism-1 | |
| GeneID-1 | |
| SwissProt-1 | |
| Organism-2 | |
| GeneID-2 | |
| SwissProt-2 | |
| Organism-3 | |
| GeneID-3 | |
| SwissProt-3 | |
| Organism-4 | |
| GeneID-4 | |
| SwissProt-4 | |
| Background | Histones are subject to a variety of enzyme-catalyzed modifications, including acetylation, methylation, phosphorylation, ubiquitination, etc. β-Hydroxybutyrylation of lysine (Kbhb) is a newly identified histone marker that is enriched in active gene promoters. Histone Kbhb marks are dramatically induced in response to elevated β-hydroxybutyrate levels in cultured cells and in livers from mice subjected to prolonged fasting or streptozotocin-induced diabetic ketoacidosis. Histone β-hydroxybutyrylation represents a new epigenetic regulatory mark that couples metabolism to gene expression, offering a new avenue to study chromatin regulation and diverse functions of β-hydroxybutyrate in the context of important human pathophysiological states, including diabetes, epilepsy, and neoplasia. |
| Cellular Localization |
