β I tubulin Monoclonal Antibody [3F7]
Ucallm_WM0988-50
Price range: $268.00 through $328.00
Product details
Background:
This gene encodes a member of the beta tubulin protein family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. This protein is specifically expressed in platelets and megakaryocytes and may be involved in proplatelet production and platelet release. A mutations in this gene is associated with autosomal dominant macrothrombocytopenia. Two pseudogenes of this gene are found on chromosome Y.[provided by RefSeq, Jul 2010],
Specifications
| Size | 50μL/100μL |
| Target | Tubulin β |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF |
| MW(Calculated) | |
| MW(Observed) | 50kD |
| Host Species | Mouse |
| Isotype | |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-10000; IF 1:200; IHC 1:50-300 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol. |
| Purification | The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | 3F7 |
| Immunogen | Synthetic Peptide of β I tubulin |
| Specificity | The antibody detects endgenousβ I tubulin proteins. |
| Gene Name | TUBB1 |
| Protein Name | Tubulin beta-1 chain |
| Other Name | TUBB1; / Tubulin beta-1 chain; / TUBB2A; / TUBB2; / Tubulin beta-2A chain; / TUBB2B; / Tubulin beta-2B chain; / TUBB4B; / TUBB2C; / Tubulin beta-4B chain; / Tubulin beta-2 chain; / Tubulin beta-2C chain; / TUBB3; / TUBB4; / Tubulin beta-3 chain; / Tubulin beta-4 chain; / Tubulin beta-III; / TUBB4A; / TUBB4; / TUBB5; / Tubulin beta-4A chain; / Tubulin 5 beta; / Tubulin beta-4 chain; / TUBB; / TUBB5; / OK/SW-cl.56; / Tubulin beta chain; / Tubulin beta-5 chain; / TUBB6; / Tubulin beta-6 chain; / TUBB8; / Tubulin beta-8 chain |
| Species | Human |
| Gene ID | 81027 |
| Uniprot | Q9H4B7, |
| Species.1 | Mouse |
| Gene ID.1 | 545486 |
| Uniprot.1 | A2AQ07 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasm, cytoskeleton . |
| Tissue Expression | Hematopoietic cell-specific. Major isotype in leukocytes, where it represents 50% of all beta-tubulins. |
| Signaling_pathway | Cellular Processes >> Transport and catabolism >> Phagosome;Cellular Processes >> Cellular community - eukaryotes >> Gap junction;Human Diseases >> Neurodegenerative disease >> Alzheimer disease;Human Diseases >> Neurodegenerative disease >> Parkinson disease;Human Diseases >> Neurodegenerative disease >> Amyotrophic lateral sclerosis;Human Diseases >> Neurodegenerative disease >> Huntington disease;Human Diseases >> Neurodegenerative disease >> Prion disease;Human Diseases >> Neurodegenerative disease >> Pathways of neurodegeneration - multiple diseases |
| Research Areas | >>Phagosome; / >>Gap junction; / >>Alzheimer disease; / >>Parkinson disease; / >>Amyotrophic lateral sclerosis; / >>Huntington disease; / >>Prion disease; / >>Pathways of neurodegeneration - multiple diseases; / >>Pathogenic Escherichia coli infection; / >>Salmonella infection |
| Function | Function:Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain.,similarity:Belongs to the tubulin family.,subunit:Dimer of alpha and beta chains., |
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