Name: 14-3-3 η Polyclonal Antibody
SKU: WP10848
Price: 268 USD
Availability: InStock

14-3-3 η Polyclonal Antibody

Ucallm_WP10848-50

Price range: $268.00 through $328.00

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50μl

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SKU: WP10848-100

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Product details

Background:

This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and bovine orthologs. This gene contains a 7 bp repeat sequence in its 5' UTR, and changes in the number of this repeat have been associated with early-onset schizophrenia and psychotic bipolar disorder. [provided by RefSeq, Jun 2009],

Specifications

Size	50μL/100μL
Target	14-3-3 eta
Reactivity	Human, Mouse, Rat
Applications	WB, IHC, IF, ELISA
MW(Calculated)
MW(Observed)	42kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:5000; Not yet tested in other applications. / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	The antiserum was produced against synthesized peptide derived from human 14-3-3 eta. AA range:51-100
Specificity	14-3-3 η Polyclonal Antibody detects endogenous levels of 14-3-3 η protein.
Gene Name	YWHAH YWHA1
Protein Name	14-3-3 protein eta
Other Name	YWHAH; / YWHA1; / 14-3-3 protein eta; / Protein AS1
Species	Human
Gene ID	7533
Uniprot	Q04917,
Species.1	Mouse
Gene ID.1	22629
Uniprot.1	P68510,
Species.2	Rat
Gene ID.2	25576
Uniprot.2	P68511
Cellular Localization	cytoplasm,mitochondrion,cytosol,plasma membrane,intercalated disc,cytoplasmic vesicle membrane,extracellular exosome,
Tissue Expression	Expressed mainly in the brain and present in other tissues albeit at lower levels.
Signaling_pathway	Cellular Processes >> Cell growth and death >> Cell cycle;Environmental Information Processing >> Signal transduction >> Hippo signaling pathway;Environmental Information Processing >> Signal transduction >> PI3K-Akt signaling pathway
Research Areas	>>Cell cycle; / >>Oocyte meiosis; / >>PI3K-Akt signaling pathway; / >>Hippo signaling pathway; / >>Hepatitis C; / >>Viral carcinogenesis
Function	Function:Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.,similarity:Belongs to the 14-3-3 family.,subunit:Homodimer (By similarity). Interacts with many nuclear hormone receptors and cofactors including AR, ESR1, ESR2, MC2R, NR3C1, NRIP1, PPARBP and THRA. Interacts with ABL1 (phosphorylated form); the interaction retains it in the cytoplasm. Interacts with RGNEF and PCTK1 (By similarity). Weakly interacts with CDKN1B.,tissue specificity:Expressed mainly in the brain and present in other tissues albeit at lower levels.,

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14-3-3 η Polyclonal Antibody

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14-3-3 η Polyclonal Antibody

Product details

Specifications

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