Need Help? +(1)-866-986-9598
0 My Cart$0.00
Home/Reagents/Antibody/Primary antibody/Polyclonal Antibody/Rabbit pAb/14-3-3 θ/τ Polyclonal Antibody
SKU: WP10850 Categories: ,

14-3-3 θ/τ Polyclonal Antibody

Ucallm_WP10850-50

Price range: $268.00 through $328.00

SKU: WP10850-100
Enter the quantity you would like, or drag the panel to find the quantity and price that best for you
Bulk QuoteAuthorize OEM & ODM

Product details

Background:

This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse and rat orthologs. This gene is upregulated in patients with amyotrophic lateral sclerosis. It contains in its 5' UTR a 6 bp tandem repeat sequence which is polymorphic, however, there is no correlation between the repeat number and the disease. [provided by RefSeq, Jul 2008],

Specifications

Size50μL/100μL
Target14-3-3 θ/τ
ReactivityHuman, Mouse, Rat
ApplicationsWB, IHC, IF, ELISA
MW(Calculated)
MW(Observed)28kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:5000; Not yet tested in other applications. / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenThe antiserum was produced against synthesized peptide derived from human 14-3-3 thet/tau. AA range:196-245
Specificity14-3-3 θ/τ Polyclonal Antibody detects endogenous levels of 14-3-3 θ/τ protein.
Gene NameYWHAQ
Protein Name14-3-3 protein theta
Other NameYWHAQ; / 14-3-3 protein theta; / 14-3-3 protein T-cell; / 14-3-3 protein tau; / Protein HS1
SpeciesHuman
Gene ID10971
UniprotP27348,
Species.1Mouse
Gene ID.122630
Uniprot.1P68254,
Species.2Rat
Gene ID.225577
Uniprot.2P68255
Cellular LocalizationCytoplasm. In neurons, axonally transported to the nerve terminals.
Tissue ExpressionAbundantly expressed in brain, heart and pancreas, and at lower levels in kidney and placenta. Up-regulated in the lumbar spinal cord from patients with sporadic amyotrophic lateral sclerosis (ALS) compared with controls, with highest levels of expression in individuals with predominant lower motor neuron involvement.
Signaling_pathwayCellular Processes >> Cell growth and death >> Cell cycle;Environmental Information Processing >> Signal transduction >> Hippo signaling pathway;Environmental Information Processing >> Signal transduction >> PI3K-Akt signaling pathway
Research Areas>>Cell cycle; / >>Oocyte meiosis; / >>PI3K-Akt signaling pathway; / >>Hippo signaling pathway; / >>Hepatitis C; / >>Hepatitis B; / >>Viral carcinogenesis
FunctionFunction:Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.,similarity:Belongs to the 14-3-3 family.,subcellular location:In neurons, axonally transported to the nerve terminals.,subunit:Homodimer. Interacts with PCTK1 (By similarity). Interacts with SSH1. Interacts with CDKN1B ('Thr-198' phosphorylated form); the interaction translocates CDKN1B to the cytoplasm.,tissue specificity:Abundantly expressed in brain, heart and pancreas, and at lower levels in kidney and placenta. Up-regulated in the lumbar spinal cord from patients with sporadic amyotrophic lateral sclerosis (ALS) compared with controls, with highest levels of expression in individuals with predominant lower motor neuron involvement.,
Please login to post questions

Related products

Western blot analysis of lysates from K562 cells, using α smooth muscle actin Rabbit mAb. The HRP-conjugated Goat anti-Rabbit IgG antibody (WS0002) was used to detect the antibody.
Sku: WR4021
Categories: ,

U-Blot® α smooth muscle actin Rabbit mAb

0 Reviews
Price range: $268.00 through $328.00
Select options
Sku: WR4004
Categories: ,

U-Blot® Cleaved PARP1 Rabbit mAb

0 Reviews
Price range: $268.00 through $328.00
Select options
Sku: WR4003
Categories: ,

U-Blot® PMS2 Rabbit mAb

0 Reviews
Price range: $268.00 through $328.00
Select options
Western blot analysis of lysates from PT0004R cells, using GAPDH Rabbit mAb. The HRP-conjugated Goat anti-Rabbit IgG antibody (WS0002) was used to detect the antibody.
Sku: WR4001
Categories: ,

U-Blot® GAPDH Rabbit mAb

0 Reviews
Price range: $268.00 through $328.00
Select options
Western blot analysis of lysates from Hela cells, using Clathrin Heavy Chain 1 Rabbit mAb. The HRP-conjugated Goat anti-Rabbit IgG antibody (WS0002) was used to detect the antibody.
Sku: WR4016
Categories: ,

U-Blot® Tuberin Rabbit mAb

0 Reviews
Price range: $268.00 through $328.00
Select options
Sku: WR4022
Categories: ,

U-Blot® GSK3 β (Phospho Ser9) Rabbit mAb

0 Reviews
Price range: $288.00 through $368.00
Select options

Customer Reviews

  • Shop Categories
Menu
Need Help? +(1)-866-986-9598
Back to Top
Product has been added to your cart