Price range: $268.00 through $328.00
Background:
FABP4 encodes the fatty acid binding protein found in adipocytes. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism. [provided by RefSeq, Jul 2008],
| Size | 50μL/100μL |
| Target | A-FABP |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | 15kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:1000-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human A-FABP AA range: 80-120 |
| Specificity | This antibody detects endogenous levels of Human A-FABP |
| Gene Name | FABP4 |
| Protein Name | A-FABP |
| Other Name | Fatty acid-binding protein, adipocyte; / Adipocyte lipid-binding protein; / ALBP; / Adipocyte-type fatty acid-binding protein; / A-FABP; / AFABP; / Fatty acid-binding protein 4 |
| Species | Human |
| Gene ID | 2167 |
| Uniprot | P15090, |
| Species.1 | Mouse |
| Gene ID.1 | 11770 |
| Uniprot.1 | P04117, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | P70623 |
| Cellular Localization | Cytoplasm . Nucleus . Depending on the nature of the ligand, a conformation change exposes a nuclear localization motif and the protein is transported into the nucleus. Subject to constitutive nuclear export. . |
| Tissue Expression | |
| Signaling_pathway | Organismal Systems >> Endocrine system >> PPAR signaling pathway |
| Research Areas | >>PPAR signaling pathway; / >>Regulation of lipolysis in adipocytes |
| Function | Domain:Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.,Function:Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus.,similarity:Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.,subcellular location:Depending on the nature of the ligand, a conformation change exposes a nuclear localization motif and the protein is transported into the nucleus. Subject to constitutive nuclear export.,subunit:Homodimer. Interacts with PPARG (By similarity). Monomer., |
