AASD-PPT Polyclonal Antibody
Ucallm_WP10876-50
Price range: $268.00 through $328.00
Product details
Background:
The protein encoded by this gene is similar to Saccharomyces cerevisiae LYS5, which is required for the activation of the alpha-aminoadipate dehydrogenase in the biosynthetic pathway of lysine. Yeast alpha-aminoadipate dehydrogenase converts alpha-biosynthetic-aminoadipate semialdehyde to alpha-aminoadipate. It has been suggested that defects in the human gene result in pipecolic acidemia. [provided by RefSeq, Jul 2008],
Specifications
| Size | 50μL/100μL |
| Target | AASD-PPT |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 36kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:40000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human AASDHPPT. AA range:11-60 |
| Specificity | AASD-PPT Polyclonal Antibody detects endogenous levels of AASD-PPT protein. |
| Gene Name | AASDHPPT |
| Protein Name | L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase |
| Other Name | AASDHPPT; / CGI-80; / HAH-P; / HSPC223; / x0005; / L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase; / 4'-phosphopantetheinyl transferase; / Alpha-aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase; / AASD-PPT |
| Species | Human |
| Gene ID | 60496 |
| Uniprot | Q9NRN7, |
| Species.1 | Mouse |
| Gene ID.1 | 67618 |
| Uniprot.1 | Q9CQF6, |
| Species.2 | Rat |
| Gene ID.2 | 300328 |
| Uniprot.2 | B2RYJ4 |
| Cellular Localization | Cytoplasm, cytosol . |
| Tissue Expression | Detected in heart, skeletal muscle, placenta, testis, brain, pancreas, liver and kidney. |
| Signaling_pathway | |
| Research Areas | >>Pantothenate and CoA biosynthesis; / >>Metabolic pathways |
| Function | Catalytic activity:CoA-[4'-phosphopantetheine] + apo-[acyl-carrier-protein] = adenosine 3',5'-bisphosphate + holo-[acyl-carrier-protein].,cofactor:Binds 1 magnesium ion.,Function:Catalyzes the post-translational modification of target proteins by phosphopantetheine. Can transfer the 4'-phosphopantetheine moiety from coenzyme A to a serine residue of a broad range of acceptors, such as the acyl carrier domain of FASN.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the P-Pant transferase superfamily. AcpS family.,subunit:Monomer. Interacts with FASN.,tissue specificity:Detected in heart, skeletal muscle, placenta, testis, brain, pancreas, liver and kidney., |
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