AATM Monoclonal Antibody
Ucallm_WM0010-50
Price range: $268.00 through $328.00
Product details
Background:
Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and inner-membrane mitochondrial forms, GOT1 and GOT2, respectively. GOT plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles. The two enzymes are homodimeric and show close homology. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2013],
Specifications
| Size | 50μL/100μL |
| Target | GOT2 |
| Reactivity | Human, Mouse, Rat, Monkey |
| Applications | WB, IF, ELISA |
| MW(Calculated) | 48kD |
| MW(Observed) | |
| Host Species | Mouse |
| Isotype | |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:10000; Not yet tested in other applications. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | Affinity purification |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | 1G3 |
| Immunogen | Purified recombinant fragment of human AATM expressed in E. Coli. |
| Specificity | AATM Monoclonal Antibody detects endogenous levels of AATM protein. |
| Gene Name | GOT2 |
| Protein Name | Aspartate aminotransferase, mitochondrial |
| Other Name | GOT2; / Aspartate aminotransferase; / mitochondrial; / mAspAT; / Fatty acid-binding protein; / FABP-1; / Glutamate oxaloacetate transaminase 2; / Kynurenine aminotransferase 4; / Kynurenine aminotransferase IV; / Kynurenine--oxoglutarate transaminase 4; / Kynu |
| Species | Human |
| Gene ID | 2806 |
| Uniprot | P00505, |
| Species.1 | Mouse |
| Gene ID.1 | 14719 |
| Uniprot.1 | P05202, |
| Species.2 | Rat |
| Gene ID.2 | 25721 |
| Uniprot.2 | P00507 |
| Cellular Localization | Mitochondrion matrix . Cell membrane . Exposure to alcohol promotes translocation to the cell membrane. . |
| Tissue Expression | Epithelium,Gastric mucosa,Muscle, |
| Signaling_pathway | |
| Research Areas | >>Arginine biosynthesis; / >>Alanine, aspartate and glutamate metabolism; / >>Cysteine and methionine metabolism; / >>Arginine and proline metabolism; / >>Tyrosine metabolism; / >>Phenylalanine metabolism; / >>Phenylalanine, tyrosine and tryptophan biosynthesis; / >>Metabolic pathways; / >>Carbon metabolism; / >>2-Oxocarboxylic acid metabolism; / >>Biosynthesis of amino acids; / >>Fat digestion and absorption |
| Function | Catalytic activity:L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.,cofactor:Pyridoxal phosphate.,Function:Facilitates cellular uptake of long-chain free fatty acids.,miscellaneous:In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.,similarity:Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.,subunit:Homodimer., |
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