ABCB6 rabbit pAb
Ucallm_WP6707-50
Price range: $268.00 through $328.00
Product details
Background:
Specifications
| Size | 50μL/100μL |
| Target | ABCB6 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 93kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human ABCB6 |
| Specificity | This antibody detects endogenous levels of ABCB6 at Human, Mouse,Rat |
| Gene Name | ABCB6 MTABC3 PRP UMAT |
| Protein Name | ATP-binding cassette sub-family B member 6, mitochondrial (Mitochondrial ABC transporter 3) (Mt-ABC transporter 3) (P-glycoprotein-related protein) (Ubiquitously-expressed mammalian ABC half transporter) |
| Other Name | |
| Species | Human |
| Gene ID | 10058 |
| Uniprot | Q9NP58, |
| Species.1 | Mouse |
| Gene ID.1 | 74104 |
| Uniprot.1 | Q9DC29, |
| Species.2 | Rat |
| Gene ID.2 | 140669 |
| Uniprot.2 | O70595 |
| Cellular Localization | Cell membrane; Multi-pass membrane protein . Mitochondrion outer membrane; Multi-pass membrane protein . Endoplasmic reticulum membrane; Multi-pass membrane protein . Golgi apparatus membrane; Multi-pass membrane protein . Endosome membrane; Multi-pass membrane protein . Lysosome membrane . Late endosome membrane . Early endosome membrane . Secreted, extracellular exosome . Mitochondrion . Endosome, multivesicular body membrane . Melanosome membrane . Present in the membrane of mature erythrocytes and in exosomes released from reticulocytes during the final steps of erythroid maturation (PubMed:22655043). Traffics from endoplasmic reticulum to Golgi during its glycans's maturation, therefrom is first targeted to the plasma membrane, and is rapidly internalized through endocytosis to be distributed to the limiting membrane of multivesicular bodies and lysosomes (PubMed:25627919, PubMed:21199866, PubMed:18279659). Localized on the limiting membrane of early melanosomes of pigment cells (PubMed:29940187). Targeted to the endolysosomal compartment (By similarity). . |
| Tissue Expression | Widely expressed. High expression is detected in the retinal epithelium (PubMed:10837493, PubMed:22226084). Expressed in mature erythrocytes (PubMed:22655043). |
| Signaling_pathway | |
| Research Areas | |
| Function | ATP-dependent transporter that catalyzes the transport of a broad-spectrum of porphyrins from the cytoplasm to the extracellular space through the plasma membrane or into the vesicle lumen . May also function as an ATP-dependent importer of porphyrins from the cytoplasm into the mitochondria, in turn may participate in the de novo heme biosynthesis regulation and in the coordination of heme and iron homeostasis during phenylhydrazine stress . May also play a key role in the early steps of melanogenesis producing PMEL amyloid fibrils . In vitro, it confers to cells a resistance to toxic metal such as arsenic and cadmium and against chemotherapeutics agent such as 5-fluorouracil, SN-38 and vincristin . In addition may play a role in the transition metal homeostasis (By similarity). |
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