Product details
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ABCE1 rabbit pAb
Ucallm_WP8432-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | ABCE1 |
| Reactivity | Human, Mouse |
| Applications | WB |
| MW(Calculated) | 66kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human ABCE1 |
| Specificity | This antibody detects endogenous levels of ABCE1 at Human, Mouse |
| Gene Name | ABCE1 RLI RNASEL1 RNASELI RNS4I OK/SW-cl.40 |
| Protein Name | ATP-binding cassette sub-family E member 1 (2'-5'-oligoadenylate-binding protein) (HuHP68) (RNase L inhibitor) (Ribonuclease 4 inhibitor) (RNS4I) |
| Other Name | |
| Species | Human |
| Gene ID | 6059 |
| Uniprot | P61221, |
| Species.1 | Mouse |
| Gene ID.1 | 24015 |
| Uniprot.1 | P61222 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasm . Mitochondrion . Localized to clusters of virus formation at the plasma membrane. |
| Tissue Expression | |
| Signaling_pathway | |
| Research Areas | |
| Function | Cotranslational quality control factor involved in the No-Go Decay (NGD) pathway . Together with PELO and HBS1L, is required for 48S complex formation from 80S ribosomes and dissociation of vacant 80S ribosomes . Together with PELO and HBS1L, recognizes stalled ribosomes and promotes dissociation of elongation complexes assembled on non-stop mRNAs; this triggers endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and to degrade damaged mRNAs as part of the No-Go Decay (NGD) pathway . Plays a role in the regulation of mRNA turnover (By similarity). Plays a role in quality control of translation of mitochondrial outer membrane-localized mRNA . As part of the PINK1-regulated signaling, ubiquitinated by CNOT4 upon mitochondria damage; this modification generates polyubiquitin signals that recruit autophagy receptors to the mitochondrial outer membrane and initiate mitophagy . RNASEL-specific protein inhibitor which antagonizes the binding of 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) to RNASEL . Negative regulator of the anti-viral effect of the interferon-regulated 2-5A/RNASEL pathway .; (Microbial infection) May act as a chaperone for post-translational events during HIV-1 capsid assembly.; (Microbial infection) Plays a role in the down-regulation of the 2-5A/RNASEL pathway during encephalomyocarditis virus (EMCV) and HIV-1 infections. |
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