Name: ABCG1 Polyclonal Antibody
SKU: WP15155
Price: 268 USD
Availability: InStock

ABCG1 Polyclonal Antibody

Ucallm_WP15155-50

Price range: $268.00 through $328.00

Size

100μl

50μl

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SKU: WP15155-100

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Product details

Background:

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. It is involved in macrophage cholesterol and phospholipids transport, and may regulate cellular lipid homeostasis in other cell types. Six alternative splice variants have been identified. [provided by RefSeq, Jul 2008],

Specifications

Size	50μL/100μL
Target	ABCG1
Reactivity	Human, Mouse, Rat
Applications	WB, IHC, IF, ELISA
MW(Calculated)
MW(Observed)	75kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-1:2000; IHC: 1:100-300; ELISA 1:10000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	Synthesized peptide derived from ABCG1 . at AA range: 560-640
Specificity	ABCG1 Polyclonal Antibody detects endogenous levels of ABCG1 protein.
Gene Name	ABCG1
Protein Name	ATP-binding cassette sub-family G member 1
Other Name	ABCG1; / ABC8; / WHT1; / ATP-binding cassette sub-family G member 1; / ATP-binding cassette transporter 8; / White protein homolog
Species	Human
Gene ID	9619
Uniprot	P45844,
Species.1	Mouse
Gene ID.1	11307
Uniprot.1	Q64343
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Endoplasmic reticulum membrane; Multi-pass membrane protein . Golgi apparatus membrane; Multi-pass membrane protein . Cell membrane . Predominantly localized in the intracellular compartments mainly associated with the endoplasmic reticulum (ER) and Golgi membranes.
Tissue Expression	Expressed in several tissues. Expressed in macrophages; expression is increased in macrophages from patients with Tangier disease.
Signaling_pathway
Research Areas	>>ABC transporters; / >>Lipid and atherosclerosis
Function	Alternative products:Additional isoforms seem to exist,Disease:Overexpressed in macrophages from patients with Tangier disease compared to control macrophages. Expressed in foamy macrophages within the atherosclerotic plaque. May play a role in the cholesterol metabolism of macrophages in vitro and in the atherosclerotic plaque.,Function:Transporter involved in macrophage lipid homeostasis. Is an active component of the macrophage lipid export complex. Could also be involved in intracellular lipid transport processes. The role in cellular lipid homeostasis may not be limited to macrophages.,induction:Strongly induced in monocyte-derived macrophages during cholesterol influx. Conversely, mRNA and protein expression are suppressed by lipid efflux. Induction is mediated by the liver X receptor/retinoid X receptor (LXR/RXR) pathway. Not induced by bacterial lipopolysaccharides (LPS). Repressed by ZNF202.,similarity:Belongs to the ABC transporter family. ABCG (White) subfamily.,similarity:Contains 1 ABC transmembrane type-2 domain.,similarity:Contains 1 ABC transporter domain.,subcellular location:Predominantly localized in the intracellular compartments mainly associated with the endoplasmic reticulum (ER) and Golgi membranes.,subunit:May form heterodimers with several heterologous partners of the ABCG subfamily.,tissue specificity:Expressed in several tissues.,