ABI3 Polyclonal Antibody
Ucallm_WP3231-50
Price range: $268.00 through $328.00
Product details
Background:
This gene encodes a member of an adaptor protein family. Members of this family encode proteins containing a homeobox homology domain, proline rich region and Src-homology 3 (SH3) domain, and are components of the Abi/WAVE complex which regulates actin polymerization. The encoded protein inhibits ectopic metastasis of tumor cells as well as cell migration. This may be accomplished through interaction with p21-activated kinase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013],
Specifications
| Size | 50μL/100μL |
| Target | ABI3 |
| Reactivity | Human, Mouse |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 40kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from part region of human protein AA range: 286-336 |
| Specificity | ABI3 Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | ABI3 NESH |
| Protein Name | ABI gene family member 3 (New molecule including SH3) (Nesh) |
| Other Name | |
| Species | Human |
| Gene ID | 51225 |
| Uniprot | Q9P2A4, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q8BYZ1 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasm . Colocalizes with PAK2 at leading edge of cells. |
| Tissue Expression | Expressed in heart, lung, liver, pancreas, kidney, placenta and at low levels in brain and skeletal muscle. |
| Signaling_pathway | |
| Research Areas | |
| Function | Function:May inhibit tumor metastasis (By similarity). In vitro, reduces cell motility.,similarity:Belongs to the ABI family.,similarity:Contains 1 SH3 domain.,subcellular location:Colocalizes with PAK2 at leading edge of cells.,subunit:May interact with PAK1 and PAK2. Probably interacts with TARSH.,tissue specificity:Expressed in heart, lung, liver, pancreas, kidney, placenta and at low levels in brain and skeletal muscle., |
Please login to post questions
Related products
