Product details
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ACD rabbit pAb
Ucallm_WP7586-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | ACD |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 50kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human ACD |
| Specificity | This antibody detects endogenous levels of ACD at Human, Mouse,Rat |
| Gene Name | ACD PIP1 PTOP TINT1 TPP1 |
| Protein Name | Adrenocortical dysplasia protein homolog (POT1 and TIN2-interacting protein) |
| Other Name | |
| Species | Human |
| Gene ID | 65057 |
| Uniprot | Q96AP0, |
| Species.1 | Mouse |
| Gene ID.1 | 497652 |
| Uniprot.1 | Q5EE38, |
| Species.2 | Rat |
| Gene ID.2 | 307798 |
| Uniprot.2 | Q4FZR5 |
| Cellular Localization | Nucleus . Chromosome, telomere . |
| Tissue Expression | |
| Signaling_pathway | |
| Research Areas | |
| Function | Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends. Without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodimer enhances telomere elongation by recruiting telomerase to telomeres and increasing its processivity. May play a role in organogenesis. |
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