SKU: WP1397 Categories: ,

ACHB4 Polyclonal Antibody

Price range: $268.00 through $328.00

SKU: WP1397-100
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Product details

Background:

function:After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane., similarity:Belongs to the ligand-gated ionic channel (TC 1.A.9) family., subunit:Neuronal AChR is composed of two different types of subunits: alpha and beta. Beta-4 subunit can be combined to alpha-2, alpha-3 or alpha-4 to give rise to functional receptors. Interacts with RIC3; which is required for proper folding and assembly.,

Specifications

Size50μL/100μL
TargetACHB4
ReactivityHuman, Mouse, Rat
ApplicationsWB, ELISA
MW(Calculated)
MW(Observed)54kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-2000; ELISA 1:5000-20000
FormulationLiquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from human protein . at AA range: 300-380
SpecificityACHB4 Polyclonal Antibody detects endogenous levels of protein.
Gene NameCHRNB4
Protein NameNeuronal acetylcholine receptor subunit beta-4
Other Name
SpeciesHuman
Gene ID1143
UniprotP30926,
Species.1Mouse
Gene ID.1
Uniprot.1Q8R493,
Species.2Rat
Gene ID.2
Uniprot.2P12392
Cellular LocalizationCell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Tissue Expression
Signaling_pathwayOrganismal Systems >> Nervous system >> Cholinergic synapse
Research Areas>>Neuroactive ligand-receptor interaction; / >>Cholinergic synapse; / >>Chemical carcinogenesis - receptor activation
FunctionFunction:After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.,similarity:Belongs to the ligand-gated ionic channel (TC 1.A.9) family.,subunit:Neuronal AChR is composed of two different types of subunits: alpha and beta. Beta-4 subunit can be combined to alpha-2, alpha-3 or alpha-4 to give rise to functional receptors. Interacts with RIC3; which is required for proper folding and assembly.,
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