Price range: $268.00 through $328.00
Background:
The protein encoded by this gene is a member of the G protein-coupled receptor family, and is a receptor for C-C type chemokines. This receptor has been shown to bind dendritic cell- and T cell-activated chemokines including CCL19/ELC, CCL21/SLC, and CCL25/TECK. A pseudogene of this gene is found on chromosome 6. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2013],
| Size | 50μL/100μL |
| Target | CCRL1 |
| Reactivity | Human, Mouse |
| Applications | WB, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 40kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:5000; Not yet tested in other applications. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human CCRL1. AA range:5-54 |
| Specificity | CCRL1 Polyclonal Antibody detects endogenous levels of CCRL1 protein. |
| Gene Name | CCRL1 |
| Protein Name | C-C chemokine receptor type 11 |
| Other Name | CCRL1; / CCBP2; / CCR11; / VSHK1; / C-C chemokine receptor type 11; / C-C CKR-11; / CC-CKR-11; / CCR-11; / CC chemokine receptor-like 1; / CCRL1; / CCX CKR |
| Species | Human |
| Gene ID | 51554 |
| Uniprot | Q9NPB9, |
| Species.1 | Mouse |
| Gene ID.1 | 252837 |
| Uniprot.1 | Q924I3 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Early endosome . Recycling endosome . Cell membrane; Multi-pass membrane protein . Predominantly localizes to endocytic vesicles, and upon stimulation by the ligand is internalized via caveolae. Once internalized, the ligand dissociates from the receptor, and is targeted to degradation while the receptor is recycled back to the cell membrane. |
| Tissue Expression | Predominantly expressed in heart. Lower expression in lung, pancreas, spleen, colon, skeletal muscle and small intestine. |
| Signaling_pathway | Environmental Information Processing >> Signaling molecules and interaction >> Cytokine-cytokine receptor interaction;Environmental Information Processing >> Signaling molecules and interaction >> Viral protein interaction with cytokine and cytokine receptor |
| Research Areas | >>Cytokine-cytokine receptor interaction; / >>Viral protein interaction with cytokine and cytokine receptor |
| Function | Function:Receptor for CCL2, CCL8, CCL13, CCL19, CCL21 and CCL25.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Predominantly expressed in heart. Lower expression in lung, pancreas, spleen, colon, skeletal muscle and small intestine., |
