Price range: $268.00 through $328.00
Background:
The product of this gene belongs to the acyl-CoA oxidase family. It encodes the branched-chain acyl-CoA oxidase which is involved in the degradation of long branched fatty acids and bile acid intermediates in peroxisomes. Deficiency of this enzyme results in the accumulation of branched fatty acids and bile acid intermediates, and may lead to Zellweger syndrome, severe mental retardation, and death in children. [provided by RefSeq, Mar 2009],
| Size | 50μL/100μL |
| Target | ACOX2 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 74kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 270-350 |
| Specificity | ACOX2 Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | ACOX2 |
| Protein Name | Peroxisomal acyl-coenzyme A oxidase 2 (3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-CoA 24-hydroxylase) (3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-CoA oxidase) (Trihydroxycoprostanoyl-CoA oxidase) (THCA-CoA oxidase) (THCCox) |
| Other Name | |
| Species | Human |
| Gene ID | 8309 |
| Uniprot | Q99424, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q9QXD1, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | P97562 |
| Cellular Localization | Peroxisome . |
| Tissue Expression | Present in all tissues tested: heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Most abundant in heart, liver and kidney. |
| Signaling_pathway | Cellular Processes >> Transport and catabolism >> Peroxisome;Organismal Systems >> Endocrine system >> PPAR signaling pathway |
| Research Areas | >>Primary bile acid biosynthesis; / >>Metabolic pathways; / >>PPAR signaling pathway; / >>Peroxisome |
| Function | Catalytic activity:(25R)-3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestan-26-oyl-CoA + H(2)O + acceptor = (24R,25R)-3-alpha,7-alpha,12-alpha,24-tetrahydroxy-5-beta-cholestan-26-oyl-CoA + reduced acceptor.,cofactor:FAD.,Disease:Absent in patients suffering from Zellweger syndrome.,Function:Oxidizes the CoA esters of the bile acid intermediates di- and tri-hydroxycholestanoic acids.,similarity:Belongs to the acyl-CoA oxidase family.,subunit:Heterodimer.,tissue specificity:Present in all tissues tested: heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Most abundant in heart, liver and kidney., |
