ADAMTS-12 Polyclonal Antibody
Ucallm_WP10948-50
Price range: $268.00 through $328.00
Product details
Background:
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS-1) motif. Individual members of this family differ in the number of C-terminal TS-1 motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains eight TS-1 motifs. It may play roles in pulmonary cells during fetal development or in tumor processes through its proteolytic activity or as a molecule potentially involved in regulation of cell adhesion. [provided by RefSeq, Jul 2008],
Specifications
| Size | 50μL/100μL |
| Target | ADAMTS-12 |
| Reactivity | Human, Mouse |
| Applications | IHC, IF, ELISA |
| MW(Calculated) | 178kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:100-1:300; ELISA 1:20000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from ADAMTS-12 . at AA range: 1100-1180 |
| Specificity | ADAMTS-12 Polyclonal Antibody detects endogenous levels of ADAMTS-12 protein. |
| Gene Name | ADAMTS12 |
| Protein Name | A disintegrin and metalloproteinase with thrombospondin motifs 12 |
| Other Name | ADAMTS12; / A disintegrin and metalloproteinase with thrombospondin motifs 12; / ADAM-TS 12; / ADAM-TS12; / ADAMTS-12 |
| Species | Human |
| Gene ID | 81792 |
| Uniprot | P58397, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q811B3 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Secreted, extracellular space, extracellular matrix . |
| Tissue Expression | Expressed in skeletal muscle and fat. |
| Signaling_pathway | |
| Research Areas | |
| Function | cofactor:Binds 1 zinc ion per subunit.,Domain:The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.,Domain:The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix.,PTM:Subjected to an intracellular maturation process yielding a 120 kDa N-terminal fragment containing the metalloproteinase, disintegrin, one TSP type-1 and the Cys-rich domains and a 83 kDa C-terminal fragment containing the spacer 2 and four TSP type-1 domains.,PTM:The precursor is cleaved by a furin endopeptidase.,similarity:Contains 1 disintegrin domain.,similarity:Contains 1 peptidase M12B domain.,similarity:Contains 1 PLAC domain.,similarity:Contains 8 TSP type-1 domains.,tissue specificity:Expressed exclusively in fetal lung. Is widely expressed in gastric carcinomas and in cancer cells of diverse origin., |
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