Name: ADH1G rabbit pAb
SKU: WP4197
Price: 268 USD
Availability: InStock

ADH1G rabbit pAb

Ucallm_WP4197-50

Price range: $268.00 through $328.00

Size

100μl

50μl

Clear

SKU: WP4197-100

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Product details

Background:

This gene encodes class I alcohol dehydrogenase, gamma subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class I alcohol dehydrogenase, consisting of several homo- and heterodimers of alpha, beta, and gamma subunits, exhibits high activity for ethanol oxidation and plays a major role in ethanol catabolism. Three genes encoding alpha, beta and gamma subunits are tandemly organized in a genomic segment as a gene cluster. [provided by RefSeq, Jul 2008],

Specifications

Target	ADH1G
Reactivity	Human
Applications	WB
MW(Calculated)	41kD
MW(Observed)
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Modification
Recommended Dilution Ratio	WB 1:500-2000
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	Synthesized peptide derived from human ADH1G AA range: 185-235
Sequence
Specificity	This antibody detects endogenous levels of ADH1G at Human
Gene Name	ADH1C ADH3
Protein Name	ADH1G
Other Name
Species	Human
Gene ID-1	126
Uniprot	P00326
Species.1
Gene ID-2
Uniprot.1
Species.2
Gene ID-3
Uniprot.2
Organism-4
Gene ID-4
SwissProt-4
Background	This gene encodes class I alcohol dehydrogenase, gamma subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class I alcohol dehydrogenase, consisting of several homo- and heterodimers of alpha, beta, and gamma subunits, exhibits high activity for ethanol oxidation and plays a major role in ethanol catabolism. Three genes encoding alpha, beta and gamma subunits are tandemly organized in a genomic segment as a gene cluster. [provided by RefSeq, Jul 2008],
Cellular Localization	Cytoplasm.
Tissue Expression
Signaling_pathway
Research Areas	>>Glycolysis / Gluconeogenesis; / >>Fatty acid degradation; / >>Tyrosine metabolism; / >>Pyruvate metabolism; / >>Retinol metabolism; / >>Metabolism of xenobiotics by cytochrome P450; / >>Drug metabolism - cytochrome P450; / >>Metabolic pathways; / >>Alcoholic liver disease
Function	Catalytic activity:An alcohol + NAD(+) = an aldehyde or ketone + NADH.,cofactor:Binds 2 zinc ions per subunit.,miscellaneous:There are 7 different ADH's isozymes in human: three belongs to class-I: alpha, beta, and gamma, one to class-II: pi, one to class-III: chi, one to class-IV: ADH7 and one to class-V: ADH6.,polymorphism:Three alleles are known: ADH1B1 (ADH21) corresponding to variant beta-1, ADH1B2 (ADH22) corresponding to variant beta-2, ADH1B3 (ADH23) corresponding to variant beta-3. The sequence shown is that of allele ADH1B1. The ADH1B2 allele frequency in orientals is approximately 75%, whereas it is less than 5% in most Caucasian populations.,polymorphism:Two main alleles are known, ADH31 or gamma-1 has Arg-272/Ile-350 while ADH32 or gamma-2 has Gln-272/Val-350. ADH31 is associated with a fast rate of ethanol oxidation and ADH32 with a slow rate.,similarity:Belongs to the zinc-containing alcohol dehydrogenase family.,subunit:Dimer of identical or non-identical chains of three types; alpha, beta and gamma.,
RRID

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ADH1G rabbit pAb

Product details

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ADH1G rabbit pAb

Product details

Specifications

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