SKU: WP10967 Categories: ,

ADK Polyclonal Antibody

Price range: $268.00 through $328.00

SKU: WP10967-100
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Product details

Background:

This gene an enzyme which catalyzes the transfer of the gamma-phosphate from ATP to adenosine, thereby serving as a regulator of concentrations of both extracellular adenosine and intracellular adenine nucleotides. Adenosine has widespread effects on the cardiovascular, nervous, respiratory, and immune systems and inhibitors of the enzyme could play an important pharmacological role in increasing intravascular adenosine concentrations and acting as anti-inflammatory agents. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011],

Specifications

Size50μL/100μL
TargetADK
ReactivityHuman, Mouse, Rat
ApplicationsWB, IF, ELISA
MW(Calculated)
MW(Observed)40kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:20000; Not yet tested in other applications.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenThe antiserum was produced against synthesized peptide derived from human ADK. AA range:1-50
SpecificityADK Polyclonal Antibody detects endogenous levels of ADK protein.
Gene NameADK
Protein NameAdenosine kinase
Other NameADK; / Adenosine kinase; / AK; / Adenosine 5'-phosphotransferase
SpeciesHuman
Gene ID132
UniprotP55263,
Species.1Mouse
Gene ID.111534
Uniprot.1P55264,
Species.2Rat
Gene ID.225368
Uniprot.2Q64640
Cellular Localization[Isoform 1]: Nucleus .; [Isoform 2]: Cytoplasm .
Tissue ExpressionWidely expressed. Highest level in placenta, liver, muscle and kidney.
Signaling_pathway
Research Areas>>Purine metabolism; / >>Metabolic pathways; / >>Nucleotide metabolism
FunctionCatalytic activity:ATP + adenosine = ADP + AMP.,cofactor:Binds 3 magnesium ions per subunit.,Function:ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. Serves as a potential regulator of concentrations of extracellular adenosine and intracellular adenine nucleotides.,pathway:Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenosine: step 1/1.,similarity:Belongs to the carbohydrate kinase pfkB family.,subunit:Monomer.,tissue specificity:Widely expressed. Highest level in placenta, liver, muscle and kidney.,
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