SKU: WP16182 Categories: ,

ADR1 rabbit pAb

Price range: $268.00 through $328.00

SKU: WP16182-100
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Product details

Background:

This gene encodes a protein which acts as a receptor for adiponectin, a hormone secreted by adipocytes which regulates fatty acid catabolism and glucose levels. Binding of adiponectin to the encoded protein results in activation of an AMP-activated kinase signaling pathway which affects levels of fatty acid oxidation and insulin sensitivity. A pseudogene of this gene is located on chromosome 14. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2014],

Specifications

Size50μL/100μL
TargetADR1
ReactivityHuman, Mouse
ApplicationsWB
MW(Calculated)41kD
MW(Observed)
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-2000
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from human ADR1 AA range: 277-327
SpecificityThis antibody detects endogenous levels of ADR1 at Human/Mouse
Gene NameADIPOR1 PAQR1 TESBP1A CGI-45
Protein NameADR1
Other Name
SpeciesHuman
Gene ID51094
UniprotQ96A54,
Species.1Mouse
Gene ID.172674
Uniprot.1Q91VH1
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationCell membrane; Multi-pass membrane protein . Localized to the cell membrane and intracellular organelles. .
Tissue ExpressionWidely expressed (PubMed:16044242). Highly expressed in heart and skeletal muscle (PubMed:12802337). Expressed at intermediate level in brain, spleen, kidney, liver, placenta, lung and peripheral blood leukocytes (PubMed:12802337). Weakly expressed in colon, thymus and small intestine (PubMed:12802337).
Signaling_pathwayOrganismal Systems >> Endocrine system >> Adipocytokine signaling pathway;Organismal Systems >> Aging >> Longevity regulating pathway;Environmental Information Processing >> Signal transduction >> AMPK signaling pathway
Research Areas>>AMPK signaling pathway; / >>Longevity regulating pathway; / >>Adipocytokine signaling pathway; / >>Non-alcoholic fatty liver disease; / >>Alcoholic liver disease
FunctionFunction:Receptor for globular and full-length adiponectin (APM1), an essential hormone secreted by adipocytes that acts as an antidiabetic. Probably involved in metabolic pathways that regulate lipid metabolism such as fatty acid oxidation. Mediates increased AMPK, PPARA ligand activity, fatty acid oxidation and glucose uptake by adiponectin. Has some high-affinity receptor for globular adiponectin but low-affinity receptor for full-length adiponectin.,similarity:Belongs to the ADIPOR family.,subcellular location:Localized to the cell membrane and intracellular organelles.,subunit:May form homo and heteromultimers.,tissue specificity:Widely expressed. Highly expressed in skeletal muscle. Expressed at intermediate level in brain, heart, spleen, kidney, liver, placenta, lung and peripheral blood leukocytes. Weakly expressed in colon, thymus and small intestine.,
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