Product details
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AF-6 rabbit pAb
Ucallm_WP8530-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | AFDN |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 201kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human AF-6 |
| Specificity | This antibody detects endogenous levels of AF-6 at Human, Mouse,Rat |
| Gene Name | MLLT4 AF6 |
| Protein Name | Afadin (ALL1-fused gene from chromosome 6 protein) (Protein AF-6) |
| Other Name | |
| Species | Human |
| Gene ID | 4301 |
| Uniprot | P55196, |
| Species.1 | Mouse |
| Gene ID.1 | 17356 |
| Uniprot.1 | Q9QZQ1, |
| Species.2 | Rat |
| Gene ID.2 | 26955 |
| Uniprot.2 | O35889 |
| Cellular Localization | Cell junction, adherens junction . Not found at cell-matrix AJs. . |
| Tissue Expression | |
| Signaling_pathway | Cellular Processes >> Cellular community - eukaryotes >> Adherens junction;Cellular Processes >> Cellular community - eukaryotes >> Tight junction;Organismal Systems >> Immune system >> Leukocyte transendothelial migration;Environmental Information Processing >> Signal transduction >> Ras signaling pathway;Environmental Information Processing >> Signal transduction >> Rap1 signaling pathway;Environmental Information Processing >> Signal transduction >> cAMP signaling pathway |
| Research Areas | |
| Function | Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs) (By similarity). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton . May play a key role in the organization of epithelial structures of the embryonic ectoderm (By similarity). Essential for the organization of adherens junctions . |
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